ArticleCell stem cell2020
Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
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Article in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 1 of them a synthesis that pooled it.
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141citing papers in PubMed, 1 pooled it
15.2field-weighted citation impact, top 1% of its field
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Who cites it
141 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Comprehensive Integration of Multiple Single-Cell Transcriptomic Data Sets Defines Distinct Cell Populations and Their Phenotypic Changes in Murine Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2024Pooled it
- Vascular calcification: pathogenic mechanisms, signaling crosstalk and translational therapeutics.Signal transduction and targeted therapy · 2026Review
- Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability.Current atherosclerosis reports · 2026Review
- SNAI2/SLUG: a key regulator of endothelial-to-mesenchymal transition and vascular remodeling in cardiovascular diseases.Journal of cardiothoracic surgery · 2026Review
- Metabolic control of smooth muscle cell phenotype switching in atherosclerosis.Science advances · 2026Article
- Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).Molecular medicine reports · 2026Review
- Endothelial progenitor cells are associated with improved vascular repair in experimental aortic dissection.Scientific reports · 2026Article
- Circular RNA-mediated regulation of key signaling pathways in cardiovascular diseases: a review.Journal of advanced research · 2026Review
- Erosion or Explosion: Integrated Single-Cell Transcriptomics Reveals Cellular Heterogeneity in Aortic Aneurysm and Dissection.Inflammation · 2026Article
- Associations between cardio-ankle vascular index score, an indicator of arteriosclerosis and aortic volume and hemodynamic parameters using four-dimensional magnetic resonance imaging.BMC cardiovascular disorders · 2026Article
- Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus.Scientific reports · 2026Article
- ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis.Cardiovascular research · 2026Article
- HDL Regulates TGFβ-Receptor Lipid Raft Partitioning, Restoring Contractile Features of Cholesterol-Loaded Vascular Smooth Muscle Cells.JACC. Basic to translational science · 2026Article
- Smooth muscle cell phenotypic modulation during atherosclerosis.Vascular pharmacology · 2026Review
- Cell-dependent contributions of thrombospondin-1 to the rupture of abdominal aortic aneurysm in mice.Cardiovascular research · 2026Article
- A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease.Biomolecules · 2026Review
- Endothelial-Mesenchymal transition in cerebrovascular diseases: molecular mechanisms and promising pharmacological strategies.Molecular biology reports · 2026Review
- Editorial: Molecular advances and new insights in aortic aneurysmal diseases.Frontiers in cell and developmental biology · 2026Article
- Endothelial Metabolic Reprogramming Links Diabetes to Atherosclerosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Transplantation of iPSC-derived vascular wall-like tissue for improved embolization and reconstruction of aneurysm sac in endovascular aneurysm repair.Frontiers in bioengineering and biotechnology · 2026Article
81 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 7 institutions in 3 countries.
Pei-Yu ChenYale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Lingfeng QinDepartment of Surgery, Yale University School of Medicine, New Haven, CT, USA.
Guangxin LiDepartment of Surgery, Yale University School of Medicine, New Haven, CT, USA; Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, Guangdong Province, China.
Jose Malagon-LopezComputational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA; Complex Biological Systems Alliance, Medford, MA, USA.
Zheng WangSchool of Basic Medicine, Qingdao University, Shandong, China.
Sonia BergayaDepartment of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, NY, USA.
Sharvari GujjaComputational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA; Complex Biological Systems Alliance, Medford, MA, USA.
Alexander W CaulkDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Sae-Il MurtadaDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Xinbo ZhangVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Zhen W ZhuangYale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Deepak A RaoDivision of Rheumatology, Inflammation, Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Guilin WangDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
Zuzana TobiasovaDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Bo JiangDepartment of Surgery, Yale University School of Medicine, New Haven, CT, USA; Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China.
Ruth R MontgomeryDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Lele SunGenomics Laboratory, WuXiNextCODE, Shanghai, China.
Hongye SunGenomics Laboratory, WuXiNextCODE, Shanghai, China.
Edward A FisherDepartment of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, NY, USA.
Jeffrey R GulcherCancer Genetics Group, WuXi NextCODE, Cambridge, MA, USA.
Carlos Fernandez-HernandoVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
George TellidesDepartment of Surgery, Yale University School of Medicine, New Haven, CT, USA. Electronic address: george.tellides@yale.edu.
Thomas W ChittendenComputational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXiNextCODE, Cambridge, MA, USA; Complex Biological Systems Alliance, Medford, MA, USA; Division of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: tchittenden@wuxinextcode.com.
Michael SimonsYale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: michael.simons@yale.edu.
Yale University · USIntel (United States) · USNew York University · USBoston Children's Hospital · USBrigham and Women's Hospital · USCancer Genetics (United States) · USQingdao University · CN
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MSystems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4MTGFB-Dependent Mechanoresponses by Aortic Smooth Muscle Cells Govern AneurysmsP01HL134605 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HUMPHREY, JAY D. · 2018 to 2022
$12.1MMolecular Regulation of Atherosclerosis Regression - RenewalR01HL084312 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHER, EDWARD A · 2006 to 2024
$11.4MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MEndothelial-to-mesenchyma transition and atherosclerosisR01HL135582 · NHLBI · YALE UNIVERSITY · PI SCHWARTZ, MARTIN A, SIMONS, MICHAEL · 2017 to 2024
$6.6MImproving Tissue Engineered Vascular Graft Performance via Computational ModelingR01HL139796 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2018 to 2025
$6.4MNovel insights into the molecular and cellular mechanism regulating lipid metabolism and atherosclerosisR35HL135820 · NHLBI · YALE UNIVERSITY · PI FERNANDEZ HERNANDO, CARLOS · 2017 to 2023
$6.0MBiomechanical Simulation of Evolving Aortic Aneurysms for Designing InterventionR01HL086418 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D. · 2008 to 2017
$3.8MAn innate immune checkpoint in cancer immunotherapy.R01CA212376 · NCI · YALE UNIVERSITY · PI GHOSH, SOURAV, ROTHLIN, CARLA · 2017 to 2021
$3.1MSmooth Muscle Cell Proliferation and Degradative Phenotype in Thoracic Aorta Aneurysm and DissectionR01HL146723 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D., TELLIDES, GEORGE · 2019 to 2022
$2.9MA super-resolution microscope for research and educationS10OD020142 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2015 to 2015
$600kNCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA212376NHLBI NIH HHS P01 HL134605NHLBI NIH HHS R01 HL084312NHLBI NIH HHS R01 HL086418NHLBI NIH HHS R01 HL134712NHLBI NIH HHS R01 HL135582NHLBI NIH HHS R01 HL139796NHLBI NIH HHS R01 HL146723NHLBI NIH HHS R35 HL135820NIAID NIH HHS U19 AI089992NIAMS NIH HHS P30 AR070253NIH HHS S10 OD020142
Abstract
The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) signaling in smooth muscle. Here, we investigated the interactions between these different factors in aortic aneurysm development and identified a key role for smooth muscle cell (SMC) reprogramming into a mesenchymal stem cell (MSC)-like state. SMC-specific ablation of TGF-β signaling in Apoe
Indexed as
Aortic AneurysmMuscle, Smooth, VascularAnimalsAortaCellular ReprogrammingMiceMyocytes, Smooth MuscleTransforming Growth Factor betaTransforming Growth Factor betaaneurysmaortaartificial intelligenceatherosclerosiscell fatecell reprogrammingmesenchymal stem cellscRNA-seqsmooth muscle cellsTGF-beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.