Evidence map›Paper›PMID 32243764›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

E-Cigarette or Vaping Product Use-associated Lung Injury: Developing a Research Agenda. An NIH Workshop Report.

Laura E Crotty Alexander, Lorraine B Ware, Carolyn S Calfee, Sean J Callahan, Thomas Eissenberg, Carol Farver, Maciej L Goniewicz, Ilona Jaspers, Farrah Kheradmand, Talmadge E King and 6 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Electronic Cigarettes: A Pro-Con Review of the Current Literature.The journal of allergy and clinical immunology. In practice · 2022
    Review
  11. Article
  12. Article
  13. Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  14. Article
  15. Article
  16. E-Cigarette Toxicology.Annual review of pharmacology and toxicology · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Sex differences in the induction of angiotensin converting enzyme 2 (ACE-2) in mouse lungs after e-cigarette vapor exposure and its relevance to COVID-19.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Laura E Crotty AlexanderDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, San Diego, California.
Lorraine B WareDepartment of Medicine and.
Carolyn S CalfeeDivision of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, California.
Sean J CallahanDivision of Pulmonary and Critical Care, University of Utah Health, Salt Lake City, Utah.ORCID 0000-0003-2182-7704
Thomas EissenbergDepartment of Psychology and.
Carol FarverDepartment of Pathology, University of Michigan, Ann Arbor, Michigan.
Maciej L GoniewiczDepartment of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Ilona JaspersDepartment of Pediatrics and.
Farrah KheradmandBaylor College of Medicine, Houston, Texas.
Talmadge E KingDivision of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, California.
Nuala J MeyerDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Vladimir B MikheevBattelle Memorial Institute, Columbus, Ohio.
Peter G ShieldsComprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Alan ShihadehAerosol Research Lab, American University of Beirut, Beirut, Lebanon; and.
Robert StronginDepartment of Chemistry, Portland State University, Portland, Oregon.
Robert TarranDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
WNY Center for Research on Flavored Tobacco Products (CRoFT)U54CA228110 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI BANSAL-TRAVERS, MAANSI · 2018 to 2022
$19.8M
Toxicant Production and Mitigation in the Electronic-Cigarette Reaction VesselR01ES025257 · NIEHS · PORTLAND STATE UNIVERSITY · PI STRONGIN, ROBERT M · 2015 to 2019
$3.6M
Integrated risk assessment and molecular characterization of pulmonary response to e-cigarette exposureR01HL139335 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI MIKHEEV, VLADIMIR B, QIAN, WEI-JUN · 2018 to 2021
$2.4M
E-cig flavors and their effects on respiratory innate immune responsesR01HL139369 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA · 2017 to 2020
$2.4M
Electronic Cigarette Vapor Inhalation Adversely Affects Lung Cellular and Physiologic Function and Alters Systemic Inflammatory PathwaysR01HL137052 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CROTTY ALEXANDER, LAURA ELISE · 2017 to 2021
$2.3M
Toxic Effects of Ecigs Following Transition From Conventional CigarettesR01ES029442 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI KHERADMAND, FARRAH · 2018 to 2020
$1.6M
Impact of novel Heat-not-Burn cigarettes on pulmonary inflammation and immunityR01HL142511 · NHLBI · ROSWELL PARK CANCER INSTITUTE CORP · PI GONIEWICZ, MACIEJ LUKASZ, THANAVALA, YASMIN · 2019 to 2021
$1.5M
Hypoxia inducible factors in pulmonary endothelial cells regulate allergic inflammatory airways diseaseI01BX004767 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CROTTY ALEXANDER, LAURA ELISE · 2020 to 2023
–
BLRD VA I01 BX004767NCI NIH HHS P30 CA016086NCI NIH HHS U54 CA228110NHLBI NIH HHS R01 HL137052NHLBI NIH HHS R01 HL139335NHLBI NIH HHS R01 HL139369NHLBI NIH HHS R01 HL142511NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES025257NIEHS NIH HHS R01 ES029442
6 · The paper itself

Abstract

The NHLBI convened a working group on October 23, 2019, to identify the most relevant and urgent research priorities and prevailing challenges in e-cigarette or vaping product use-associated lung injury (EVALI). Experts across multiple disciplines discussed the complexities of the EVALI outbreak, identified research priorities, and recommended strategies to address most effectively its causal factors and improve diagnosis, treatment, and prevention of this disease. Many research priorities were identified, including the need to create national and international registries of patients with EVALI, to track accurately those affected and assess outcomes. The group concluded that biospecimens from subjects with EVALI are urgently needed to help define EVALI pathogenesis and that vaping has disease risks that are disparate from smoking, with the occurrence of EVALI highlighting the importance of broadening e-cigarette research beyond comparators to smoking-related diseases.

Indexed as

Electronic Nicotine Delivery SystemsPractice Guidelines as TopicAdultAgedAged, 80 and overCongresses as TopicFemaleHumansLung InjuryMaleMiddle AgedNational Heart, Lung, and Blood Institute (U.S.)National Institutes of Health (U.S.)Research ReportRespiratory TherapyUnited Statese-cigaretteEVALIresearchTHCvaping

Identifiers

PMID32243764
PMCPMC7491408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.