ArticleMagnetic resonance in medicine2020
Motion-robust, high-SNR liver fat quantification using a 2D sequential acquisition with a variable flip angle approach.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Quantifying Pancreatic Fat Using a Free-Breathing Acquisition in Adults With Obesity Undergoing Diet-Induced Weight Loss-Results From the LION Study.NMR in biomedicine · 2026Trial
- Free-Breathing Fat Quantification Using a Phase Error-Corrected Cartesian Acquisition With Spiral Profile Ordering.Magnetic resonance in medicine · 2026Article
- Highly Reproducible, Vendor-Agnostic, Motion-Insensitive Liver PDFF Mapping at 0.55T, 1.5T, and 3T.Magnetic resonance in medicine · 2026Article
- Optimized motion-insensitive PDFF mapping of the liver.Magnetic resonance in medicine · 2026Article
- Motion-Insensitive Flip Angle Modulated Liver Proton Density Fat-Fraction and R2* Mapping During Free-Breathing MRI in a Clinical Setting.Journal of magnetic resonance imaging : JMRI · 2025Observational
- Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024Review
- Automated MR Image Prescription of the Liver Using Deep Learning: Development, Evaluation, and Prospective Implementation.Journal of magnetic resonance imaging : JMRI · 2023Article
- Liver cirrhosis in children - the role of imaging in the diagnostic pathway.Pediatric radiology · 2023Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeChemical shift encoded (CSE)-MRI enables quantification of proton-density fat fraction (PDFF) as a biomarker of liver fat content. However, conventional 3D Cartesian CSE-MRI methods require breath-holding. A motion-robust 2D Cartesian sequential method addresses this limitation but suffers from low SNR. In this work, a novel free breathing 2D Cartesian sequential CSE-MRI method using a variable flip angle approach with centric phase encoding (VFA-centric) is developed to achieve fat quantification with low
methodsNumerical simulation was performed for variable flip angle schedule design and preliminary evaluation of VFA-centric method, along with several alternative flip angle designs. Phantom, adults (n = 8), and children (n = 27) were imaged at 3T. Multi-echo images were acquired and PDFF maps were estimated. PDFF standard deviation was used as a surrogate for SNR.
resultsIn both simulation and phantom experiments, the VFA-centric method enabled higher SNR imaging with minimal
conclusionsThe proposed free breathing 2D Cartesian sequential CSE-MRI method with variable flip angle approach and centric-ordered phase encoding achieved motion robustness, low
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