ArticlePloS one2020
Alterations in the structural characteristics of rectus abdominis muscles caused by diabetes and pregnancy: A comparative study of the rat model and women.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Prevalence of Symptomatic Established Rectus Diastasis of Parity in Primiparous Women: A Prospective Cohort Study From Early Pregnancy to 1-Year Postpartum.World journal of surgery · 2026Article
- Relationship between lower urinary system symptoms and urinary incontinence in women with gestational diabetes.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Gestational and Type 2 Diabetes in Relation to Urinary Incontinence in Black Women in the U.S.Uro · 2025Article
- Ex vivo myo-mechanical assessment of isolated rectus abdominis muscle in pregnancy-specific urinary incontinence: a cross-sectional study nested within the Diamater cohort.Biomedical engineering online · 2025Article
- Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis.Scientific reports · 2024Article
- The role of Gestational Diabetes Mellitus and pelvic floor 3D-ultrasound assessment during pregnancy predicting urinary incontinence: a prospective cohort study.BMC pregnancy and childbirth · 2023Article
- Gestational diabetes mellitus and pelvic floor function 6 weeks postpartum in Chinese women.International urogynecology journal · 2023Article
- Impact of Obesity and Hyperglycemia on Pregnancy-specific Urinary Incontinence.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function.International urogynecology journal · 2022Article
- Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence.International journal of molecular sciences · 2022Article
- Viability of ex-vivo myography as a diagnostic tool for rectus abdominis muscle electrical activity collected at Cesarean section within a diamater cohort study.Biomedical engineering online · 2022Article
- Reversal of diabetic-induced myopathy by swimming exercise in pregnant rats: a translational intervention study.Scientific reports · 2022Article
- Gestational diabetes is associated with alteration on pelvic floor muscle activation pattern during pregnancy and postpartum: Prospective cohort using electromyography assessment.Frontiers in endocrinology · 2022Article
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16 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveIn the present study, we compared the effect of diabetic pregnancy on the rectus abdominis muscle (RAM) in humans and rats. We hypothesized that our animal model could provide valuable information about alterations in the RAM of women with Gestational Diabetes (GDM).
methodNewborns female rats (n = 10/group) were administered streptozotocin (100 mg/kg body weight) subcutaneously and were mated on reaching adulthood, to develop the mild hyperglycemic pregnant (MHP) rat model. At the end of pregnancy, the mothers were sacrificed, and the RAM tissue was collected. Pregnant women without GDM (non-GDM group; n = 10) and those diagnosed with GDM (GDM group; n = 8) and undergoing treatment were recruited, and RAM samples were obtained at C-section. The RAM architecture and the distribution of the fast and slow fibers and collagen were studied by immunohistochemistry.
resultsNo statistically significant differences in the maternal and fetal characters were observed between the groups in both rats and women. However, significant changes in RAM architecture were observed. Diabetes in pregnancy increased the abundance of slow fibers and decreased fast fiber number and area in both rats and women. A decrease in collagen distribution was observed in GDM women; however, a similar change was not observed in the MHP rats.
conclusionOur results indicated that pregnancy- associated diabetes- induced similar structural adaptations in the RAM of women and rats with slight alterations in fiber type number and area. These findings suggest that the MHP rat model can be used for studying the effects of pregnancy-associated diabetes on the fiber structure of RAM.
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