ArticlePLoS neglected tropical diseases2020
Persistent deleterious effects of a deleterious Wolbachia infection.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Comparison of Oviposition and Adult Trapping to Monitor wMel Introgression for Wolbachia-Based Vector Control.The American journal of tropical medicine and hygiene · 2026Article
- Rethinking microbial biopesticide development and uptake.World journal of microbiology & biotechnology · 2026Review
- Changes in the frequency of facultative endosymbionts in insect populations: overview and applications.Entomologia generalis · 2025Article
- Cytoplasmic incompatibility factor proteins fromProceedings. Biological sciences · 2025Article
- RevisitingEcology and evolution · 2024Article
- Article
- Aedes aegypti microbiome composition covaries with the density of Wolbachia infection.Microbiome · 2023Article
- Fitness costs of Wolbachia shift in locally-adapted Aedes aegypti mosquitoes.Environmental microbiology · 2022Article
- Genomic and Phenotypic Comparisons Reveal Distinct Variants ofApplied and environmental microbiology · 2022Article
- Wolbachia inhibits ovarian formation and increases blood feeding rate in female Aedes aegypti.PLoS neglected tropical diseases · 2022Article
- Establishment of Wolbachia infection in Aedes aegypti from Pakistan via embryonic microinjection and semi-field evaluation of general fitness of resultant mosquito population.Parasites & vectors · 2022Article
- Why did theEvolution letters · 2022Article
- A decade of stability for wMel Wolbachia in natural Aedes aegypti populations.PLoS pathogens · 2022Article
- AApplied and environmental microbiology · 2021Article
- Growth and Maintenance ofInsects · 2021Review
- Article
- Infertility and fecundity loss of Wolbachia-infected Aedes aegypti hatched from quiescent eggs is expected to alter invasion dynamics.PLoS neglected tropical diseases · 2021Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wolbachia are being used to reduce dengue transmission by Aedes aegypti mosquitoes around the world. To date releases have mostly involved Wolbachia strains with limited fitness effects but strains with larger fitness costs could be used to suppress mosquito populations. However, such infections are expected to evolve towards decreased deleterious effects. Here we investigate potential evolutionary changes in the wMelPop infection transferred from Drosophila melanogaster to Aedes aegypti more than ten years (~120 generations) ago. We show that most deleterious effects of this infection have persisted despite strong selection to ameliorate them. The wMelPop-PGYP infection is difficult to maintain in laboratory colonies, likely due to the persistent deleterious effects coupled with occasional maternal transmission leakage. Furthermore, female mosquitoes can be scored incorrectly as infected due to transmission of Wolbachia through mating. Infection loss in colonies was not associated with evolutionary changes in the nuclear background. These findings suggest that Wolbachia transinfections with deleterious effects may have stable phenotypes which could ensure their long-term effectiveness if released in natural populations to reduce population size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.