Trial reportPloS one2020
Frailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study.
Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis.European geriatric medicine · 2023Pooled it
- Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD.NPJ primary care respiratory medicine · 2023Pooled it
- Dynamic frailty trajectories and risk of chronic obstructive pulmonary disease: a large-scale prospective cohort study.BMC pulmonary medicine · 2026Article
- Frailty Is a Predictor of Disability, Hospitalization and Mortality in Older Adults with COPD: A Longitudinal Study.Journal of clinical medicine · 2026Article
- Assessment of peak inspiratory flow in patients with chronic obstructive pulmonary disease: a multicentre, observational, prospective, real-life study.BMJ open respiratory research · 2025Observational
- Prevalence, Persistence, and Agreement of Physical Frailty Tools in Patients with Severe COPD Declining Pulmonary Rehabilitation: An Exploratory 1-Year Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Association of changes in frailty with mortality in the aged with hypertension.Scientific reports · 2025Article
- Advances in pathophysiology and assessment methods of chronic obstructive pulmonary disease with frailty.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Relationship Between COPD Progression and Frailty Progression: A Five-year Observation in Real Clinical Practice.International journal of chronic obstructive pulmonary disease · 2025Observational
- Association between frailty index and all-cause mortality in hospitalized elderly patients with osteoporotic fractures: a retrospective cohort study.Frontiers in medicine · 2025Article
- Frailty and Exacerbation of Chronic Obstructive Pulmonary Disease: Is There Any Association?International journal of chronic obstructive pulmonary disease · 2024Article
- The Role of Pulmonary Function Testing in the Diagnosis and Management of COPD.Respiratory care · 2023Review
- Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2023Article
- Association between B-vitamins intake and frailty among patients with chronic obstructive pulmonary disease.Aging clinical and experimental research · 2023Article
- Is Frailty Diagnosis Important in Patients with COPD? A Narrative Review of the Literature.International journal of environmental research and public health · 2023Review
- Frailty and Mortality Risk in COPD: A Cohort Study Comparing the Fried Frailty Phenotype and Short Physical Performance Battery.International journal of chronic obstructive pulmonary disease · 2023Article
- Association between COVID-19 morbidity, mortality, and gross domestic product, overweight/ obesity, non-communicable diseases, vaccination rate: A cross-sectional study.Journal of infection and public health · 2022Article
- Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease.Biomedicines · 2021Article
- A Frailty Assessment Tool to Predict In-Hospital Mortality in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2021Article
- Weak Handgrip at Index Admission for Acute Exacerbation of COPD Predicts All-Cause 30-Day Readmission.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough frailty is a frequent occurrence in chronic obstructive pulmonary disease (COPD) patients, evidence on the frequency of frailty transition is scarce.
aimsThe present study aimed to describe the frailty status transition rates over a 2-year period and their associated clinical outcomes in stable COPD patients, and to determine predictors of improvement in frailty status.
methodsWe prospectively included 119 patients with stable COPD (mean age ± SD, 66.9 ± 7.9 years) over a follow-up period of 2 years. Frailty was assessed using the Fried criteria (unintentional weight loss, weakness, exhaustion, low activity level, and slow walking speed). Several demographic, clinical, and health-related variables were measured. We calculated the rates for each of the frailty transitions (no change, improvement, or worsening) between baseline and 2 years. Outcomes were compared using one-way analysis of variance and predictors of improvement were identified in multivariate logistic regression.
resultsAfter 2 years of follow-up, 21 (17.6%) patients had an improved frailty status, 14 (11.7%) had worsened, and 84 (70.5%) had maintained the same frailty status. The worsening group (vs no change group) had greater dyspnea (p = 0.013) and disability (p = 0.036) and lower handgrip strength (p = 0.001). In contrast, the improved group (vs no change group) had greater handgrip (p<0.001) and quadriceps strength (p = 0.032). Furthermore, the improved group had greater handgrip strength (p<0.001), quadriceps strength (p = 0.003), physical activity (p = 0.008), and lower disability (p = 0.019) than the worsening group. Additionally, we determined that the 5STS test (≤ 13.6s) and exacerbations (≥ 2) were independent predictors for improvement in frailty status [adjusted OR 9.46, p = 0.058 and adjusted OR 0.12, p = 0.026, respectively].
conclusionsFrailty is a dynamic process for approximately one-third of patients with stable COPD and transitions in frailty status are associated with significant changes in clinical outcomes. The 5STS and exacerbations were independent predictors of improvement in frailty status.
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