SynthesisMedicine2020
Explore structural and functional brain changes in insomnia disorder: A PRISMA-compliant whole brain ALE meta-analysis for multimodal MRI.
Synthesis in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Distinct Convergent Brain Alterations in Sleep Disorders and Sleep Deprivation: A Meta-Analysis.JAMA psychiatry · 2025Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Convergent abnormality in the subgenual anterior cingulate cortex in insomnia disorder: A revisited neuroimaging meta-analysis of 39 studies.Sleep medicine reviews · 2023Pooled it
- Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Brain Functional and Structural Changes in Alzheimer's Disease With Sleep Disorders: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Altered Neurofluid Dynamics Markers in Middle-Aged and Older Women With Insomnia: A Multiparametric MR Neuroimaging Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Altered cortical neuronal activity in functional esophageal disorders and its associations with chronic insomnia and peripheral inflammation: a resting-state fMRI study.Frontiers in molecular neuroscience · 2026Article
- Article
- Sleep discrepancy and brain glucose metabolism in community-dwelling older adults.Aging brain · 2024Article
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
- Article
- The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment.Journal of gerontological nursing · 2023Article
- Association between the Pittsburgh sleep quality index and white matter integrity in healthy adults: a whole-brain magnetic resonance imaging study.Sleep and biological rhythms · 2023Article
- Comorbid obstructive sleep apnea and insomnia and its associations with mood and diabetes-related distress in type 2 diabetes mellitus.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- The aberrant dynamic amplitude of low-frequency fluctuations in melancholic major depressive disorder with insomnia.Frontiers in psychiatry · 2022Article
- Prefrontal brain function in patients with chronic insomnia disorder: A pilot functional near-infrared spectroscopy study.Frontiers in neurology · 2022Article
- Alterations of Resting-State Locus Coeruleus Functional Connectivity After Transdermal Trigeminal Electrical Neuromodulation in Insomnia.Frontiers in psychiatry · 2022Article
- Orbitofrontal and Cingulate Thickness Asymmetry Associated with Depressive Symptom Dimensions.Cognitive, affective & behavioral neuroscience · 2021Article
- ENIGMA-Sleep: Challenges, opportunities, and the road map.Journal of sleep research · 2021Review
- Depressive Symptoms in Comorbid Obstructive Sleep Apnea and Insomnia: An Integrative Review.Western journal of nursing research · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inconsistent results for comparison between insomnia disorder (ID) patients and healthy controls (HC) were obtained from previous neuroimaging studies. An activation likelihood estimation (ALE) meta-analysis was made for multimodal neuroimaging in ID. ALE analysis indicated that ID patients showed significant gray matter reductions in the right middle frontal gyrus (MFG), compared to HC. Regarding positron emission tomography studies, ALE analysis showed reduced relative cerebral glucose metabolism in the right amygdala, the right anterior cingulate cortex (ACC), and the right posterior cingulate gyrus (PCG) in ID patients, compared to HC. Regarding diffusion tensor imaging studies, the present study indicated that ID patients showed reduced fractional anisotropy values in the left putamen and the right caudate body, compared to HC. Additionally, ID patients showed reduced amplitude of low frequency fluctuations (ALFF) in the left fusiform gyrus (FG), the left middle temporal gyrus (MTG), the right MTG, the right anterior lobe (AL), and the left PCG, compared to HC. ID patients showed increased ALFF in the left MFG, compared to HC. ID patients showed reduced regional homogeneity (ReHo) in the left parahippocampal gyrus, the left sublobar, the left cuneus, the left precentral gyrus (PCG), the right AL, the right ACC, and the right PCG, compared to HC. ID patients showed increased ReHo in the left FG, the left precuneus, and the right cingulate gyrus, compared to HC. Moreover, the ALE analysis showed hypoactivation relative to HC in the left superior temporal gyrus (STG), the left MTG, the right inferior frontal gyrus, the right cuneus, and the right STG in ID patients. Via this ALE meta-analysis, we obtained these key regions suffering from deficits in ID.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.