Evidence map›Paper›PMID 32243310›Full record

SynthesisJournal of lower genital tract disease2020

A Systematic Review of Tests for Postcolposcopy and Posttreatment Surveillance.

Megan A Clarke, Elizabeth R Unger, Rosemary Zuna, Erin Nelson, Teresa M Darragh, Miriam Cremer, Colleen K Stockdale, Mark H Einstein, Nicolas Wentzensen

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of lower genital tract disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Risk factors analysis of recurrent disease after treatment with a loop electrosurgical excision procedure for high-grade cervical intraepithelial neoplasia.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 1 country.

Megan A ClarkeDivision of Cancer Epidemiology & Genetics, National Cancer Institute/NIH, Bethesda, MD.
Elizabeth R UngerCenters for Disease Control, Atlanta, GA.
Rosemary ZunaDepartment of Pathology, College of Medicine, University of Oklahoma, Oklahoma City, OK.
Erin NelsonDepartment of Obstetrics and Gynecology, University of Texas San Antonio, San Antonio, TX.
Teresa M DarraghDepartment of Pathology, University of California San Francisco, San Francisco, CA.
Miriam CremerWomen's Health, Cleveland Clinic, Cleveland, OH.
Colleen K StockdaleDepartment of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA.
Mark H EinsteinDepartment of Obstetrics, Gynecology & Women's Health, Rutgers New Jersey Medical School, Newark, NJ.
Nicolas WentzensenDivision of Cancer Epidemiology & Genetics, National Cancer Institute/NIH, Bethesda, MD.
Centers for Disease Control and Prevention · USCleveland Clinic · USDivision of Cancer Epidemiology and GeneticsNational Cancer Institute · USRutgers New Jersey Medical SchoolThe University of Texas at San Antonio · USUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Oklahoma · US

Funding

Cervical Cancer MoonshotZIACP010230 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHIFFMAN, MARK · 2018 to 2025
$33.8M
Human papillomavirus (HPV) infection and cervical and anal cancersZIACP010124 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI WENTZENSEN, NICOLAS · 2009 to 2025
$17.3M
CERVICAL CANCER AND HUMAN PAPILLOMAVIRUS (HPV) INFECTIONZ01CP010124 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHIFFMAN, MARK · 1996 to 2008
$3.0M
Intramural NIH HHS Z01 CP010124Intramural NIH HHS ZIA CP010124
6 · The paper itself

Abstract

objectiveFor the 2019 ASCCP Risk-Based Management Consensus Guidelines, we conducted a systematic review of diagnostic assays for postcolposcopy and posttreatment management. MATERIALS AND

methodsA literature search was conducted to identify articles reporting on tests/assays for cervical cancer screening, triage, postcolposcopy surveillance, and posttreatment surveillance published between 2012 and 2019 in PubMed and Embase. Titles and abstracts were evaluated by co-authors for inclusion. Included articles underwent full-text review, data abstraction, and quality assessment. Pooled absolute pretest and posttest risk estimates were calculated for studies evaluating management of patients after treatment.

resultsA total of 2,862 articles were identified through the search. Of 50 articles on postcolposcopy, 5 were included for data abstraction. Of 66 articles on posttreatment, 23 were included for data abstraction and were summarized in the meta-analysis. The pooled posttreatment risk of cervical intraepithelial neoplasia (CIN) 2+ in all studies was 4.8% (95% CI = 3.4%-6.8%), ranging from 0.4%-19.5% (τ = 0.57) in individual studies. Among individuals testing negative for human papillomavirus (HPV) posttreatment, the risk of CIN 2+ was 0.69% (95% CI = 0.3%-1.5%); among individuals testing positive for HPV posttreatment, the risk of CIN 2+ was 18.3% (95% CI = 12.1%-26.6%) in all studies. All risk estimates were substantially higher for liquid-based cytology. The HPV-cytology co-testing provided slightly better reassurance compared with HPV alone at the cost of much higher positivity.

conclusionsDespite a large number of published studies on postcolposcopy and posttreatment surveillance, only few met criteria for abstraction and were included in the meta-analysis. More high-quality studies are needed to evaluate assays and approaches that can improve management of patients with abnormal screening.

Indexed as

ColposcopyFemaleHumansPapillomaviridaePractice Guidelines as TopicRisk AssessmentUterine Cervical NeoplasmsVaginal Smears

Identifiers

PMID32243310
PMCPMC7141755
OpenAlexW3014847213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.