ArticleBiomacromolecules2020
Multivalency Enables Dynamic Supramolecular Host-Guest Hydrogel Formation.
Article in Biomacromolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Highly Tunable and Cell-Remodelable Thiol-ene Alginate-Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication.Advanced healthcare materials · 2026Article
- Designing Dynamic Hydrogels: The Interplay of Cross-Linker Length, Valency, and Reaction Kinetics in Hydrazone-Based Networks.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Injectable Granular Hydrogels Enable Avidity-Controlled Biotherapeutic Delivery.ACS biomaterials science & engineering · 2024Article
- Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles.Chemical science · 2023Article
- Enzymatic post-crosslinking of printed hydrogels of methacrylated gelatin and tyramine-conjugated 8-arm poly(ethylene glycol) to prepare interpenetrating 3D network structures.International journal of bioprinting · 2023Article
- Chemical strategies to engineer hydrogels for cell culture.Nature reviews. Chemistry · 2022Review
- Tuning the affinity of amphiphilic guest molecules in a supramolecular polymer transient network.RSC advances · 2022Article
- Application of Alginate-Based Hydrogels in Hemostasis.Gels (Basel, Switzerland) · 2022Review
- Protein Assembly by Design.Chemical reviews · 2021Review
- Supramolecular Host-Guest Hydrogels for Corneal Regeneration.Gels (Basel, Switzerland) · 2021Review
- From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances.International journal of molecular sciences · 2021Review
- From Snapshots to Development: Identifying the Gaps in the Development of Stem Cell-based Embryo Models along the Embryonic Timeline.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Mechanical Properties of a Supramolecular Nanocomposite Hydrogel Containing Hydroxyl Groups Enriched Hyper-Branched Polymers.Polymers · 2021Article
- The rheology of direct and suspended extrusion bioprinting.APL bioengineering · 2021Review
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Supramolecular and dynamic biomaterials hold promise to recapitulate the time-dependent properties and stimuli-responsiveness of the native extracellular matrix (ECM). Host-guest chemistry is one of the most widely studied supramolecular bonds, yet the binding characteristics of host-guest complexes (β-CD/adamantane) in relevant biomaterials have mostly focused on singular host-guest interactions or nondiscrete multivalent pendent polymers. The stepwise synergistic effect of multivalent host-guest interactions for the formation of dynamic biomaterials remains relatively unreported. In this work, we study how a series of multivalent adamantane (guest) cross-linkers affect the overall binding affinity and ability to form supramolecular networks with alginate-CD (Alg-CD). These binding constants of the multivalent cross-linkers were determined via NMR titrations and showed increases in binding constants occurring with multivalent constructs. The higher multivalent cross-linkers enabled hydrogel formation; furthermore, an increase in binding and gelation was observed with the inclusion of a phenyl spacer to the cross-linker. A preliminary screen shows that only cross-linking Alg-CD with an 8-arm-multivalent guest results in robust gel formation. These cytocompatible hydrogels highlight the importance of multivalent design for dynamically cross-linked hydrogels. These materials hold promise for development toward cell- and small molecule-delivery platforms and allow discrete and fine-tuning of network properties.
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