Evidence map›Paper›PMID 32243132›Full record

ArticleACS infectious diseases2020

Radiosynthesis and Biodistribution of

Filipa Mota, Ravindra Jadhav, Camilo A Ruiz-Bedoya, Alvaro A Ordonez, Mariah H Klunk, Joel S Freundlich, Sanjay K Jain

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Radiolabeled Antimicrobials for Infection Imaging: A Scoping Review.International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Improved Radiosynthesis of [ACS infectious diseases · 2025
    Article
  6. European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  7. Observational
  8. Review
  9. Review
  10. Article
  11. Article
  12. Recent Advancements in Radiopharmaceuticals for Infection Imaging.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  13. Article
  14. Spatiotemporal perspectives on tuberculosis chemotherapy.Current opinion in microbiology · 2023
    Review
  15. DynamicNature communications · 2022
    Article
  16. Review
  17. Review
  18. Review
  19. One Size Fits All? Not inFrontiers in cellular and infection microbiology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ravindra JadhavDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, United States.
Camilo A Ruiz-Bedoya
Mariah H Klunk
Joel S FreundlichDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey 07103, United States.
Johns Hopkins University · USRutgers, The State University of New Jersey · US

Funding

Preclinical modeling to study Tuberculous MeningitisR01AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2020 to 2024
$4.0M
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Preclinical modeling to study Tuberculous MeningitisR56AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2019 to 2019
$839k
NIAID NIH HHS R01 AI145435NIAID NIH HHS R56 AI145435NIBIB NIH HHS R01 EB020539
6 · The paper itself

Abstract

Oxazolidinones are a novel class of antibacterials with excellent activity against resistant Gram-positive bacteria including strains causing multidrug-resistant tuberculosis (TB). Despite their excellent efficacy, optimal dosing strategies to limit their toxicities are still under development. Here, we developed a novel synthetic strategy for fluorine-18-radiolabeled oxazolidinones. As proof-of-concept, we performed whole-body

Indexed as

Mycobacterium tuberculosisAnimalsFluorine RadioisotopesLinezolidLungMicePositron-Emission TomographyTissue DistributionTuberculosis, Multidrug-ResistantFluorine-18Fluorine RadioisotopesLinezolidfluoride-18PETpharmacokineticstuberculosis

Identifiers

PMID32243132
PMCPMC7212803
OpenAlexW3014661578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.