ArticleHuman brain mapping2020
Breakdown of the affective-cognitive network in functional dystonia.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06328790 (A Window Into the Mind-brain-body Interplay), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Window Into the Mind-brain-body Interplay: Development of Diagnostic, Prognostic Biomarkers and Rehabilitation Strategies in Functional Motor Disorders
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Identifying diagnostic biomarkers in functional motor disorders through multimodal behavioral, neurophysiological, and imaging assessment using explainable machine learning.Journal of neurology · 2026Observational
- Functional and Structural Brain Imaging Correlates of Treatment Response in Functional Movement Disorder.Current neurology and neuroscience reports · 2026Review
- Affective and cognitive theory of mind and associated brain functional alterations in frontotemporal dementia.Brain communications · 2026Article
- Uncovering hypothalamic network disruption in ALS.Journal of neurology · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- Delineating network integration and segregation in the pathophysiology of functional neurological disorder.Brain communications · 2025Article
- The Comparison of Functional Connectivity in Parkinson's Disease Patients with and without Parkin Gene Mutations.Noro psikiyatri arsivi · 2025Article
- Interactive effect of air pollution and genetic risk of depression on processing speed by resting-state functional connectivity of occipitoparietal network.BMC medicine · 2024Article
- Biomarkers and Rehabilitation for Functional Neurological Disorder.Journal of personalized medicine · 2024Review
- Structural brain heterogeneity underlying symptomatic and asymptomatic genetic dystonia: a multimodal MRI study.Journal of neurology · 2024Article
- Article
- Dysfunctional Networks in Functional Dystonia.Advances in neurobiology · 2023Review
- Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration.Molecular psychiatry · 2022Article
- Functional MRI connectivity of the primary motor cortex in functional dystonia patients.Journal of neurology · 2022Article
- Pallidal functional connectivity changes are associated with disgust recognition in pure motor amyotrophic lateral sclerosis.NeuroImage. Clinical · 2022Article
- Altered resting-state neural networks in children and adolescents with functional neurological disorder.NeuroImage. Clinical · 2022Article
- Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.NeuroImage. Clinical · 2021Review
- Breakdown of the affective-cognitive network in functional dystonia.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies suggested that brain regions subtending affective-cognitive processes can be implicated in the pathophysiology of functional dystonia (FD). In this study, the role of the affective-cognitive network was explored in two phenotypes of FD: fixed (FixFD) and mobile dystonia (MobFD). We hypothesized that each of these phenotypes would show peculiar functional connectivity (FC) alterations in line with their divergent disease clinical expressions. Resting state fMRI (RS-fMRI) was obtained in 40 FD patients (12 FixFD; 28 MobFD) and 43 controls (14 young FixFD-age-matched [yHC]; 29 old MobFD-age-matched [oHC]). FC of brain regions of interest, known to be involved in affective-cognitive processes, and independent component analysis of RS-fMRI data to explore brain networks were employed. Compared to HC, all FD patients showed reduced FC between the majority of affective-cognitive seeds of interest and the fronto-subcortical and limbic circuits; enhanced FC between the right affective-cognitive part of the cerebellum and the bilateral associative parietal cortex; enhanced FC of the bilateral amygdala with the subcortical and posterior cortical brain regions; and altered FC between the left medial dorsal nucleus and the sensorimotor and associative brain regions (enhanced in MobFD and reduced in FixFD). Compared with yHC and MobFD patients, FixFD patients had an extensive pattern of reduced FC within the cerebellar network, and between the majority of affective-cognitive seeds of interest and the sensorimotor and high-order function ("cognitive") areas with a unique involvement of dorsal anterior cingulate cortex connectivity. Brain FC within the affective-cognitive network is altered in FD and presented specific features associated with each FD phenotype, suggesting an interaction between brain connectivity and clinical expression of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.