Evidence map›Paper›PMID 32243040›Full record

ArticleHuman brain mapping2020

Global resting-state functional connectivity of neural oscillations in tinnitus with and without hearing loss.

Carly Demopoulos, Xuan Duong, Leighton B Hinkley, Kamalini G Ranasinghe, Danielle Mizuiri, Coleman Garrett, Susanne Honma, Jennifer Henderson-Sabes, Anne Findlay, Caroline Racine-Belkoura and 2 more

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Reducing Tinnitus via Inhibitory Influence of the Sensorimotor System on Auditory Cortical Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Carly DemopoulosDepartment of Psychiatry, University of California San Francisco, San Francisco, California.ORCID 0000-0003-2082-3947
Xuan DuongDepartment of Psychology, Palo Alto University, Palo Alto, California.
Leighton B HinkleyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Kamalini G RanasingheDepartment of Neurology, University of California San Francisco, San Francisco, California.ORCID 0000-0002-4217-8785
Danielle MizuiriDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Coleman GarrettDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Susanne HonmaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Jennifer Henderson-SabesDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Anne FindlayDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Caroline Racine-BelkouraDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California.
Steven W CheungDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, California.ORCID 0000-0003-1724-4944
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USPalo Alto University · US

Funding

Pilot Clinical Trial of Deep Brain Stimulation for TinnitusU01DC013029 · NIDCD · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHEUNG, STEVEN WAN, LARSON, PAUL · 2013 to 2017
$3.4M
Vocal sensorimotor control and voice abnormalities in Autism Spectrum DisordersK23DC016637 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEMOPOULOS, CARLY · 2018 to 2022
$1.0M
Neurophysiological Assessments of Network Dysfunction in Alzheimer's DiseaseK08AG058749 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANASINGHE, KAMALINI GAYATHREE · 2019 to 2023
$859k
NIA NIH HHS K08 AG058749NIDCD NIH HHS K23 DC016637NIDCD NIH HHS K23DC016637-01A1NIDCD NIH HHS U01 DC013029NIDCD NIH HHS U01DC013029
6 · The paper itself

Abstract

This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band-dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.

Indexed as

ConnectomeMagnetoencephalographyAdultAgedAged, 80 and overAuditory CortexBrain WavesCerebral CortexFemaleHearing LossHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetSeverity of Illness Indexbiomarkerselectroencephalographyfunctional brain imaginghearing lossmagnetoencephalographytinnitus

Identifiers

PMID32243040
PMCPMC7294064
OpenAlexW3014207245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.