Evidence map›Paper›PMID 32242944›Full record

ArticleArtificial organs2020

Ultrasound-based estimation of remaining cardiac function in LVAD-supported ex vivo hearts.

Louis S Fixsen, Niels J Petterson, Patrick Houthuizen, Marcel C M Rutten, Frans N van de Vosse, Richard G P Lopata

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Louis S FixsenCardiovascular Biomechanics group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0001-5191-3502
Niels J PettersonCardiovascular Biomechanics group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-9339-3071
Patrick HouthuizenDepartment of Cardiology, Catharina Hospital, Eindhoven, The Netherlands.
Marcel C M RuttenCardiovascular Biomechanics group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Frans N van de VosseCardiovascular Biomechanics group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Richard G P LopataCardiovascular Biomechanics group, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0001-6618-6184
Eindhoven University of Technology · NLRadboud University Nijmegen · NL

Funding

European Commission H2020H2020 642612H2020 Marie Skłodowska-Curie Actions 642612
6 · The paper itself

Abstract

Left ventricular assist devices (LVAD) provide cardiac support to patients with advanced heart failure. Methods that can directly measure remaining LV function following device implantation do not currently exist. Previous studies have shown that a combination of loading (LV pressure) and deformation (strain) measurements enables quantitation of myocardial work. We investigated the use of ultrasound (US) strain imaging and pressure-strain loop analysis in LVAD-supported hearts under different hemodynamic and pump unloading conditions, with the aim of determining LV function with and without LVAD support. Ex vivo porcine hearts (n = 4) were implanted with LVADs and attached to a mock circulatory loop. Measurements were performed at hemodynamically defined "heart conditions" as the hearts deteriorated from baseline. Hemodynamic (including LV pressure) and radio-frequency US data were acquired during a pump-ramp protocol at speeds from 0 (with no pump outflow) to 10 000 revolutions per minute (rpm). Regional circumferential (ε

Indexed as

Heart-Assist DevicesAnimalsEchocardiographyHeart FailureHemodynamicsSwineVentricular Function, Leftechocardiographyex vivo heartheart failureleft ventricular assist devicespressure-strain loopsspeckle tracking

Identifiers

PMID32242944
PMCPMC7496524
OpenAlexW3014486877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.