ArticleMedical mycology2020
Deep fungal infections diagnosed by histology in Uganda: a 70-year retrospective study.
Article in Medical mycology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Histoplasmosis: A systematic review to inform the World Health Organization of a fungal priority pathogens list.Medical mycology · 2024Pooled it
- The global burden of chromoblastomycosis.PLoS neglected tropical diseases · 2021Pooled it
- Burden and Challenges in the Diagnosis and Treatment of Histoplasmosis Among Persons With Advanced HIV Disease in Uganda, 2025.Open forum infectious diseases · 2026Article
- Gastrointestinal Basidiobolomycosis Mimicking Adhesive Bowel Disease and Ileocaecal Malignancy in an Adult HIV Patient: A Case Report Highlighting a Diagnostic Pitfall.International medical case reports journal · 2026Article
- Evolving Epidemiology, Improving Diagnostic Tests and Their Importance for the Correct Diagnosis of Histoplasmosis.Journal of fungi (Basel, Switzerland) · 2025Review
- Clinical experience of primary subcutaneous mycoses in Shanghai: a retrospective analysis.Frontiers in cellular and infection microbiology · 2025Article
- A diverse spectrum of mycoses histologically diagnosed in Ghana: Insights from a 10-year retrospective study.Medical mycology · 2024Article
- Fungal diseases in Africa: Closing the gaps in diagnosis and treatment through implementation research and advocacy.Journal de mycologie medicale · 2023Review
- Implantation Mycoses and Invasive Fungal Infections with Cutaneous Involvement in Tropical Taiwan: An 11-Year Retrospective Study of a Medical Center.Journal of fungi (Basel, Switzerland) · 2023Article
- Adherence of health workers to guidelines for screening and management of cryptococcal meningitis in Uganda.PloS one · 2023Article
- Invasive Fungal Diseases in Africa: A Critical Literature Review.Journal of fungi (Basel, Switzerland) · 2022Article
- Serological evidence of chronic pulmonary Aspergillosis in tuberculosis patients in Kenya.BMC infectious diseases · 2022Article
- Endemic mycoses in South Africa, 2010-2020: A decade-long description of laboratory-diagnosed cases and prospects for the future.PLoS neglected tropical diseases · 2022Article
- Medical Mycology dissertation topics require prioritisation among Postgraduate Microbiology trainees of Makerere University, Uganda.IJID regions · 2022Article
- Evaluation of the Diagnostic Performance of a Semiquantitative Cryptococcal Antigen Point-of-Care Assay among HIV-Infected Persons with Cryptococcal Meningitis.Journal of clinical microbiology · 2021Article
- Misdiagnosis of chronic pulmonary aspergillosis as pulmonary tuberculosis at a tertiary care center in Uganda: a case series.Journal of medical case reports · 2021Article
- Epidemiology of fungal diseases in Africa: A review of diagnostic drivers.Current medical mycology · 2021Article
- Evaluation of the Dynamiker Cryptococcal Antigen Lateral Flow Assay for the Diagnosis of HIV-Associated Cryptococcosis.Journal of clinical microbiology · 2021Article
- Translational research in Uganda: linking basic science to bedside medicine in a resource limited setting.Journal of translational medicine · 2021Review
- Skin prick reactivity among asthmatics in East Africa.The World Allergy Organization journal · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Fungal infections cause substantial morbidity and mortality. However, the burden of deep fungal infections is not well described in Uganda. We aimed to estimate the burden and etiology of histologically diagnosed deep fungal infections in Uganda. We retrospectively reviewed histology reports at the Pathology Reference Laboratory, Department of Pathology, Makerere University, Kampala, Uganda from January 1950 to September 2019 to identify any reports that had a fungal infection as the diagnosis. Over the study period, 697 cases of deep fungal infections were identified with an average incidence of 0.73/100,000 persons per decade. There was a general decline in the number of cases detected. Median age of the cases was 28 years (IQR: 11-40) and majority (59%) were male. The age group of 0-10 years were the most affected. The foot was the most affected part of the body (26%). Deep mycoses identified include eumycetoma (32%), subcutaneous phycomycosis (26%), histoplasmosis (9.2%), chromoblastomycosis (4.6%), aspergillosis (3.3%), cryptococcosis (3.3%), blastomycosis (1.6%), subcutaneous mycosis (1.4%), dermatomycosis (1.3%), coccidioidomycosis (0.6%), mucormycosis (0.6%), and sporotrichosis (0.1%). Histoplasma was the commonest causative agent (9.2%) followed by Aspergillus (3.4%) and Cryptococcus (3.3%), while 81% of the fungal pathogens were not identified to genus/species level. Only 31% of the cases were diagnosed clinically as deep fungal infections. There is a substantial burden of deep fungal infections caused by multiple fungal pathogens in Uganda. There is need to build local capacity for mycology so as to improve on the index of clinical suspicion and diagnostic capabilities.
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