Evidence map›Paper›PMID 32242626›Full record

ArticleThe Journal of infectious diseases2020

Zika Virus Circulates at Low Levels in Western and Coastal Kenya.

Theodore A Gobillot, Caroline Kikawa, Dara A Lehman, John Kinuthia, Alison L Drake, Walter Jaoko, Kishorchandra Mandaliya, Grace John-Stewart, R Scott McClelland, Julie Overbaugh

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
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  7. Arthropod-borne diseases among travellers arriving in Europe from Africa, 2015 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Theodore A GobillotDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Caroline KikawaDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Dara A LehmanDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
John KinuthiaResearch and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Alison L DrakeDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Walter JaokoDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Kishorchandra MandaliyaUniversity of Nairobi Institute of Tropical & Infectious Diseases, Nairobi, Kenya.
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, Washington, USA.
R Scott McClellandDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Julie OverbaughDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
University of Washington · USFred Hutch Cancer Center · USUniversity of Nairobi · KEKenyatta National Hospital · KE

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1R37AI038518 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 1999 to 2019
$12.9M
Vaginal Health and the Risk of HIV-1 Acquistion in Kenyan WomenP01HD064915 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JOHN-STEWART, GRACE C. · 2009 to 2013
$8.9M
Viral Pathogenesis Training ProgramT32AI083203 · NIAID · UNIVERSITY OF WASHINGTON · PI BLOOM, JESSE D, LAGUNOFF, MICHAEL · 2009 to 2023
$2.7M
Optimizing repeat HIV testing during pregnancy and postpartum for PMTCTK01AI116298 · NIAID · UNIVERSITY OF WASHINGTON · PI DRAKE, ALISON L · 2015 to 2019
$632k
Defining the Prevalence and Viral Genetics of Zika Virus in KenyaF30AI142870 · NIAID · UNIVERSITY OF WASHINGTON · PI GOBILLOT, THEODORE AUGUST · 2019 to 2021
$131k
NIAID NIH HHS F30 AI142870NIAID NIH HHS K01 AI116298NIAID NIH HHS R37 AI038518NIAID NIH HHS T32 AI083203NICHD NIH HHS P01 HD064915NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

backgroundZika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there.

methodsWe screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus (DENV) responses, which we found were common in coastal Kenya.

resultsTwo cases had durable ZIKV-specific antibodies and 2 cases had ZIKV antibodies at similar levels as DENV antibodies.

conclusionsThis suggests low-level ZIKV circulation in Kenya over 2 decades and sets a baseline for future surveillance efforts in East Africa.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCoinfectionDengue VirusFemaleFeverHumansKenyaPrevalenceZika VirusZika Virus InfectionAntibodies, NeutralizingAntibodies, ViralarbovirusKenyaseroprevalenceZika virus

Identifiers

PMID32242626
PMCPMC7399697
OpenAlexW3014265318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.