ReviewJournal of the American Heart Association2020
Characterization, Pathogenesis, and Clinical Implications of Inflammation-Related Atrial Myopathy as an Important Cause of Atrial Fibrillation.
Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed, 97 citations in OpenAlex.
- Echocardiography-based multimodal models for thromboembolic risk prediction in atrial fibrillation: a narrative review.Journal of thoracic disease · 2026Review
- Exploratory Modeling of Postoperative Atrial Fibrillation After Cardiac Surgery with Cardiopulmonary Bypass Using Inflammatory Biomarkers and Clinical-Surgical Factors.Medical sciences (Basel, Switzerland) · 2026Article
- The Relationship Between the Systemic Immune Inflammatory Index and Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction.The Eurasian journal of medicine · 2026Article
- Arrhythmic risk stratification in psoriatic arthritis: a retrospective, electrogram-based comparative analysis.RMD open · 2026Article
- Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026Review
- Novel genetic insights: Mendelian randomization implicates Felty Syndrome in atrial fibrillation risk.Clinical rheumatology · 2026Article
- Right Ventricular-Pulmonary Artery Coupling in Patients With Atrial Fibrillation and Changes After Catheter Ablation.Journal of the American Heart Association · 2026Article
- Predictive Value of Uric Acid-to-Albumin Ratio for Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Non-Valvular Atrial Fibrillation.Journal of inflammation research · 2026Article
- Multiparametric assessment of atrial cardiopathy in cryptogenic stroke patients: Implications for personalized clinical management.European stroke journal · 2026Article
- Discontinuing Oral Anticoagulation after Atrial Fibrillation Ablation: Time for a Paradigm Shift?US cardiology · 2026Review
- Complex interrelationship and therapeutic advances in diabetic patients with atrial fibrillation.World journal of cardiology · 2025Review
- A narrative review of epicardial adipose tissue as a predictor of cardiometabolic risk in rheumatoid arthritis patients.Annals of translational medicine · 2025Review
- Multiparametric assessment of atrial cardiopathy in cryptogenic stroke patients: Implications for personalized clinical management.European stroke journal · 2025Article
- Arrhythmias in Rheumatoid Arthritis: A Call for a Multidisciplinary Team.Life (Basel, Switzerland) · 2025Review
- Associations of Midlife Leukocyte Telomere Length With Measures of Left Atrial Function in Community-Dwelling Older Adults: The ARIC Study.Journal of the American Heart Association · 2025Observational
- Inflammasome Signaling in Cardiac Arrhythmias: Linking Inflammation, Fibrosis, and Electrical Remodeling.International journal of molecular sciences · 2025Review
- C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index as an Independent Risk Factor for Postoperative Atrial Fibrillation Recurrence.Clinical cardiology · 2025Article
- Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers.Journal of the American Heart Association · 2025Article
- Atrial FDG uptake and atrial fibrillation: A systematic review and meta-analysis.Heart rhythm O2 · 2025Article
- Catheter Ablation of Atrial Fibrillation in Patients With Psoriasis: A Multicenter Study.Journal of the American Heart Association · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, atrial fibrillation has been observed in clinical settings of prolonged hemodynamic stress, eg, hypertension and valvular heart disease. However, recently, the most prominent precedents to atrial fibrillation are metabolic diseases that are associated with adipose tissue inflammation (ie, obesity and diabetes mellitus) and systemic inflammatory disorders (ie, rheumatoid arthritis and psoriasis). These patients typically have little evidence of left ventricular hypertrophy or dilatation; instead, imaging reveals abnormalities of the structure or function of the atria, particularly the left atrium, indicative of an atrial myopathy. The left atrium is enlarged, fibrotic and noncompliant, potentially because the predisposing disorder leads to an expansion of epicardial adipose tissue, which transmits proinflammatory mediators to the underlying left atrium. The development of an atrial myopathy not only leads to atrial fibrillation, but also contributes to pulmonary venous hypertension and systemic thromboembolism. These mechanisms explain why disorders of systemic or adipose tissue inflammation are accompanied an increased risk of atrial fibrillation, abnormalities of left atrium geometry and an enhanced risk of stroke. The risk of stroke exceeds that predicted by conventional cardiovascular risk factors or thromboembolism risk scores used to guide the use of anticoagulation, but it is strongly linked to clinical evidence and biomarkers of systemic inflammation.
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