Evidence map›Paper›PMID 32242253›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Judith Olde Heuvel, Berlinda J de Wit-van der Veen, Henk G van der Poel, Elise M Bekers, Maarten R Grootendorst, Kunal N Vyas, Cornelis H Slump, Marcel P M Stokkel

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Article
  6. Article
  7. Lessons learned in application driven imaging agent design for image-guided surgery.European journal of nuclear medicine and molecular imaging · 2024
    Review
  8. Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.European journal of nuclear medicine and molecular imaging · 2024
    Review
  9. Article
  10. Review
  11. Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Article
  13. Radiation Protection and Occupational Exposure onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  14. Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China.European journal of nuclear medicine and molecular imaging · 2022
    Review
  15. Cerenkov Luminescence Imaging in Prostate Cancer: Not the Only Light That Shines.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Judith Olde HeuvelDepartment of Nuclear Medicine, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands. j.olde.heuvel@nki.nl.
Berlinda J de Wit-van der VeenDepartment of Nuclear Medicine, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Henk G van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, Netherlands.
Elise M BekersDepartment of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, Netherlands.
Maarten R GrootendorstLightpoint Medical Ltd., Chesham, UK.
Kunal N VyasLightpoint Medical Ltd., Chesham, UK.
Cornelis H SlumpTechnical Medicine Center, University of Twente, Enschede, Netherlands.
Marcel P M StokkelDepartment of Nuclear Medicine, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
The Netherlands Cancer Institute · NLLightpoint Medical (United Kingdom) · GBUniversity of Twente · NL

Funding

KWF Kankerbestrijding 15175
6 · The paper itself

Abstract

purposeCurrently, approximately 11-38% of prostate cancer (PCa) patients undergoing radical prostatectomy have a positive surgical margin (PSM) on histopathology. Cerenkov luminescence imaging (CLI) using

methodsSix patients were included in this ongoing study. Following perioperative i.v. injection of ~ 100 MBq

resultsBy using an acquisition protocol with 150 s exposure time, 8 × 8 binning and a 550 nm shortpass filter, PSMs and negative surgical margins (NSMs) were visually correctly identified on CLI in 3 of the 5 patients. Two patients had a hotspot on CLI from cancer < 0.1 mm from the excision margin.

conclusionOverall, the study showed that

trial registrationNL8256 registered at www.trialregister.nl on 04/11/20109.

Indexed as

LuminescenceProstatic NeoplasmsEdetic AcidGallium IsotopesGallium RadioisotopesHumansMaleOligopeptidesPositron Emission Tomography Computed TomographyEdetic Acidgallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesOligopeptides68-Gallium-PSMA intraoperative assessmentCerenkov imagingPositive surgical marginPrimary prostate cancer

Identifiers

PMID32242253
PMCPMC7515945
OpenAlexW3015091235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.