ArticleThe journal of nutrition, health & aging2020
Investigation of the Diet-Gut-Muscle Axis in the Osteoporotic Fractures in Men Study.
Article in The journal of nutrition, health & aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The Relationship Between Gut Microbiota, Muscle Mass and Physical Function in Older Individuals: A Systematic Review.Nutrients · 2024Pooled it
- Associations between gut microbiota and sarcopenia or its defining parameters in older adults: A systematic review.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta-analysis of randomized controlled trials.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Understanding the gut microbiota and sarcopenia: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021Pooled it
- Curcumin supplementation during high-altitude exposure modulates body composition and its relationship with gut microbiota: a randomized controlled trial.Nutrition journal · 2026Trial
- Associations between the gut microbiome and diet, body composition, and glycemic profiles: a cross-sectionalFrontiers in nutrition · 2026Article
- Multiomic analysis of different horse breeds reveals that gut microbial butyrate enhances racehorse athletic performance.NPJ biofilms and microbiomes · 2025Article
- Dietary Carbohydrate Intake, Carbohydrate Quality, and Healthy Aging in Women.JAMA network open · 2025Article
- Exopolysaccharide of Levilactobacillus brevis M-10 Improved Physiological and Biochemical Indicators and Gut Microbiota in DSS-Induced Colitis Mice.Current microbiology · 2025Review
- Gut microbiome composition: link between sports performance and protein absorption?Journal of the International Society of Sports Nutrition · 2024Article
- Characterization of oral microbiota of children with hand, foot, and mouth disease caused by enterovirus A 71.BMC infectious diseases · 2024Article
- Plant protein, fibre and physical activity solutions to address poor appetite and prevent undernutrition in older adults: study protocol for the APPETITE randomised controlled trial.The British journal of nutrition · 2024Article
- Aging Gut Microbiome in Healthy and Unhealthy Aging.Aging and disease · 2024Review
- Different sources of alfalfa hay alter the composition of rumen microbiota in mid-lactation Holstein cows without affecting production performance.Frontiers in veterinary science · 2024Article
- Aqueous Extract ofNutrients · 2023Article
- In-Depth Analysis of the Mechanism of Astaxanthin Succinate Diester in Reducing Ulcerative Colitis in C57BL/6J Mice Based on Microbiota Informatics.Molecules (Basel, Switzerland) · 2023Article
- Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle.Oxidative medicine and cellular longevity · 2022Review
- Gut-muscle crosstalk. A perspective on influence of microbes on muscle function.Frontiers in medicine · 2022Article
- Effect of voluntary exercise upon the metabolic syndrome and gut microbiome composition in mice.Physiological reports · 2021Article
- The composition of the gut microbiome differs among community dwelling older people with good and poor appetite.Journal of cachexia, sarcopenia and muscle · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the association between dietary fiber density (grams of fiber consumed per 100 kcal) with the gut-muscle axis in older adult men.
designCross-sectional study.
settingOsteoporotic Fractures in Men (MrOS) cohort participants at Visit 4 (2014-16).
participantsOlder adult men (average age, 85y) from the MrOS study. MEASUREMENTS: Men who were in the highest tertiles for dietary fiber density and the percentage of whole body lean mass were defined as T3T3 (n=42), whereas men who were in the lowest and intermediate tertiles for these variables were defined as T1T1 (n=32), T1T3 (n=24), and T3T1 (n=13), respectively. Additionally, measures of physical function, including the short physical performance battery (SPPB) score and grip strength were higher in T3T3 when compared with T1T1. Gut bacterial abundance was quantified with use of 16S v4 rRNA sequencing, and the bacterial functional potential was derived from the 16S data with PICRUSt. Chao1, ACE, Shannon, Simpson, and Fisher indices were used as measures of α-diversity. Weighted and unweighted Unifrac, and Bray-Curtis were used as measures of β-diversity. Age, physical activity score, smoking, and number of medications-adjusted DESeq2 models were used to identify bacteria and functions that were different when comparing T3T3 with T1T1, but that were not also different when comparing T3T3 with T1T3 or T3T1.
resultsα-diversity was not different, but significant differences for β-diversity (unweighted UniFrac, Bray-Curtis) were identified when comparing T3T3 with T1T1. Known butyrate-producing bacteria, including Ruminococcus, Lachnospira, and Clostridia, and gene counts for butyrate production (KEGG IDs: K01034, K01035) were higher in T3T3, when compared with T1T1.
conclusionThese data suggest that a high-fiber diet may positively impact butyrate-producing genera and gene counts, which collectively may be involved in mechanisms related to the percentage of whole body lean mass and physical functioning in older adult men. Future studies aimed at testing the causative role of this hypothesis are of interest.
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