Evidence map›Paper›PMID 32242137›Full record

ArticleCommunications biology2020

Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.

Chiara de Lucia, Tytus Murphy, Claire J Steves, Richard J B Dobson, Petroula Proitsi, Sandrine Thuret

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Wasserstein F-tests for Fréchet regression on Bures-Wasserstein manifolds.Journal of machine learning research : JMLR · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Genomic Instability and Epigenetic Changes during Aging.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Ageing in the brain: mechanisms and rejuvenating strategies.Cellular and molecular life sciences : CMLS · 2023
    Review
  15. Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator.International journal of environmental research and public health · 2023
    Review
  16. Sex-biased gene expression in nutrient-sensing pathways.Proceedings. Biological sciences · 2023
    Article
  17. Influence of the Mediterranean Diet on Healthy Aging.International journal of molecular sciences · 2023
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Chiara de LuciaDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7541-2814
Tytus MurphyDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Claire J StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Richard J B DobsonDepartment of Biostatistics and Health Informatics, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4224-9245
Petroula ProitsiDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2553-6974
Sandrine ThuretDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Sandrine.1.thuret@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1260-8083
King's College London · GB

Funding

Medical Research Council MC_PC_17214Medical Research Council MR/K500811/1Medical Research Council MR/N030087/1Medical Research Council MR/V005030/1Wellcome Trust
6 · The paper itself

Abstract

Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for the link between lifestyle and cognitive decline. Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet. Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.

Indexed as

Cellular SenescenceCognitive AgingDiet, HealthyExerciseHealthy AgingAdultAgedAged, 80 and overAge FactorsCell LineDiet, MediterraneanDiet SurveysEnergy IntakeFemaleGene-Environment InteractionGene Expression RegulationABTB1 protein, humanGRB10 Adaptor ProteinGRB10 protein, humanRepressor ProteinsSIRT1 protein, humanSirtuin 1

Identifiers

PMID32242137
PMCPMC7118127
OpenAlexW3014105327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.