ArticleNature communications2020
Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- Toughening Artificial Spider Silk via Glue-Like Nanoparticle Crosslinks.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Biomimetic Design of Biopolymer-Based Water-Resistant Food Packaging Materials.Comprehensive reviews in food science and food safety · 2026Review
- Phosphate- and pH-dependent self-assembly of recombinant spider silk proteins.Protein science : a publication of the Protein Society · 2026Article
- Hydro-Torsional Compaction for Scalable Production of Aramid Nanofiber Threads with Densely Assembled Double-Helical Nanostructures.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly.Journal of the American Chemical Society · 2026Article
- Mechanically-robust and humidity-tunable self-destructive polymers enabled by hydrogen-bond nanoconfinement.Nature communications · 2025Article
- Crosslinking, salt-induced aging, and secondary structure formation in Peptide-containing coacervates inspired by spider silk.Communications chemistry · 2025Article
- RobustSmall science · 2025Article
- Amphibian Egg Jelly as a Biocompatible Material: Physicochemical Characterization and Selective Cytotoxicity Against Melanoma Cells.Polymers · 2025Article
- An engineered self-cleavage fusion system for the production of chimaera spider silk proteins.BMC biotechnology · 2025Article
- High-yield spidroin mimics for bioinspired fibers via computational design.Frontiers in bioengineering and biotechnology · 2025Article
- Tough Hydrogels with Different Toughening Mechanisms and Applications.International journal of molecular sciences · 2024Review
- Superfast Gelation of Spider Silk-Based Artificial Silk Protein.Gels (Basel, Switzerland) · 2024Article
- Tuning the viscoelastic properties of peptide coacervates by single amino acid mutations and salt kosmotropicity.Communications chemistry · 2024Article
- Protection and Restoration of Damaged Hair via a Polyphenol Complex by Promoting Mechanical Strength, Antistatic, and Ultraviolet Protection Properties.Biomimetics (Basel, Switzerland) · 2023Article
- Self-Healing of Recombinant Spider Silk Gel and Coating.Polymers · 2023Article
- Review
- Bio-Inspired 4D Printing of Dynamic Spider Silks.Polymers · 2022Article
- Crosslinked Polypeptide Films via RAFT-Mediated Continuous Assembly of Polymers.Angewandte Chemie (International ed. in English) · 2022Article
- Spider Silk-Inspired Artificial Fibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation of mechanically strong β-sheet rich materials remains a significant challenge due to challenges involved in processing the polymers/proteins, and managing the assembly of the hydrophobic residues. Inspired by spider-silk, our approach effectively utilizes the superior mechanical toughness and stability afforded by localised β-sheet domains within an amorphous network. Using a grafting-from polymerisation approach within an amorphous hydrophilic network allows for spatially controlled growth of poly(valine) and poly(valine-r-glycine) as β-sheet forming polypeptides via N-carboxyanhydride ring opening polymerisation. The resulting continuous β-sheet nanocrystal network exhibits improved compressive strength and stiffness over the initial network lacking β-sheets of up to 30 MPa (300 times greater than the initial network) and 6 MPa (100 times greater than the initial network) respectively. The network demonstrates improved resistance to strong acid, base and protein denaturants over 28 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.