ArticleScience (New York, N.Y.)2020
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 738 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
738citing papers in PubMed, 2 pooled it
87.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
738 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,218 citations in OpenAlex.
- Targeting Ferroptosis as the Achilles' Heel of Breast Cancer: Mechanisms and Therapeutic Opportunities from a Comprehensive Systematic Review.International journal of molecular sciences · 2025Pooled it
- Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein-protein interactions, and cross-pathway communication.Apoptosis : an international journal on programmed cell death · 2025Pooled it
- Significance of GSH and HRedox report : communications in free radical research · 2026Review
- HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors.Redox report : communications in free radical research · 2026Article
- Research progress of pancreatic cancer based on ferroptosis-cuproptosis interaction (Review).Oncology letters · 2026Review
- Metabolic hallmarks of regulated cell death.Cell research · 2026Review
- Ferroptosis in cancer: molecular mechanisms, tumour microenvironment, therapeutic resistance, and clinical translation.Journal of the Egyptian National Cancer Institute · 2026Review
- Near-Infrared Triggered Rechargeable Singlet Oxygen Battery for Sustained Phototherapy: Fast Charging and Long-Lasting Discharging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Obesity Increases Atherosclerosis Susceptibility via an Intertissue miR-30e-SLC7A11 Axis.Circulation research · 2026Article
- Targeting Cystine Addiction Suppresses Breast Cancer Lung Metastasis.Cancer research · 2026Article
- Nitric-oxide propelled nanomotors sensitize tumors to ferroptosis immunotherapy via cholesterol depletion-induced tumor cells stiffening.Materials today. Bio · 2026Article
- Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.Cancer discovery · 2026Article
- Pharmacological targeting of ferroptosis in cancer: mechanisms, tumor immunity, and translational challenges.Pharmacological reports : PR · 2026Review
- Lapatinib suppresses cysteine deprivation-induced ferroptotic cell death by modulating mitochondrial function.Medical oncology (Northwood, London, England) · 2026Article
- The emerging roles of disulfidptosis in cancer.Apoptosis : an international journal on programmed cell death · 2026Review
- Cuproptosis and ferroptosis: signal pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Engineered Substrates for a Sulfurtransferase Enhance Endogenous Hydropersulfides and Inhibit Ferroptosis.Angewandte Chemie (International ed. in English) · 2026Article
- Harnessing copper-iron crosstalk: A novel strategy to combat hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2026Review
- An excitation-customized ICT-type turn-on probe for visualization of cysteine fluctuation in diverse drug-induced ferroptosis pathways.Analytical and bioanalytical chemistry · 2026Article
- Ferroptosis: Newly Emerged Regulator for Human Disease.MedComm · 2026Review
678 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 6 institutions in 2 countries.
Michael A BadgleyDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-2745-696X
Daniel M KremerDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6224-0550
H Carlo MaurerDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-2193-6014
Kathleen E DelGiornoGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-5749-8394
Ho-Joon LeeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3616-5387
Vinee PurohitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8093-5540
Irina R SagalovskiyDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-9107-6283
Alice MaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0003-4195-9819
Jonathan KapilianDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0003-3684-2173
Christina E M FirlDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Amanda R DeckerDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0001-9969-7909
Steve A SastraDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Carmine F PalermoDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Leonardo R AndradeWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-0004-5677
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8556-7481
Li ZhangRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0703-7506
Zachary P TolstykaDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Tal HirschhornDepartments of Biological Sciences and Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-9319-3531
Candice LambDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-6204-2156
Tong LiuHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Wei GuHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-1480-2368
E Scott SeeleyDepartment of Pathology, University of California, San Francisco, CA 94143, USA.
Everett StoneDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
George GeorgiouDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-8823-3073
Uri ManorWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0002-9802-1955
Alina IugaHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-2351-8289
Geoffrey M WahlGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.ORCID 0000-0003-3658-2279
Brent R StockwellDepartments of Biological Sciences and Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-3532-3868
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9309-6141
Kenneth P OliveDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA. kenolive@columbia.edu.ORCID 0000-0002-3392-8994
Columbia University Irving Medical Center · USUniversity of Michigan · USSalk Institute for Biological Studies · USThe University of Texas at Austin · USColumbia University · USUniversity of California, San Francisco · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MScientific ReagentsP01CA087497 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PRIVES, CAROL · 2000 to 2021
$35.4MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MCombining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneityR35CA197687 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WAHL, GEOFFREY MYLES · 2015 to 2021
$7.8MCELL, MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CANCERT32CA009503 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAUTIER, JEAN · 1985 to 2016
$6.8MDefining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5MTargeting cysteine import to induce ferroptotic cell death in pancreatic cancerR01CA215607 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Kenneth P. Olive · 2017 to 2026
$4.0MTargeting metabolic stress to induce pancreatic tumor cell deathR01CA244931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$1.9MGenetic and pharmacological manipulation of system xc in pancreatic cancerF31CA180738 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BADGLEY, MICHAEL ALEXANDER · 2013 to 2017
$172kNCI NIH HHS F31 CA180738NCI NIH HHS P01 CA087497NCI NIH HHS P30 CA013696NCI NIH HHS P30 CA014195NCI NIH HHS R01 CA215607NCI NIH HHS R01 CA244931NCI NIH HHS R35 CA197687NCI NIH HHS R35 CA209896NCI NIH HHS T32 CA009503NIDDK NIH HHS U24 DK097153
Abstract
Ferroptosis is a form of cell death that results from the catastrophic accumulation of lipid reactive oxygen species (ROS). Oncogenic signaling elevates lipid ROS production in many tumor types and is counteracted by metabolites that are derived from the amino acid cysteine. In this work, we show that the import of oxidized cysteine (cystine) via system x
Indexed as
FerroptosisAnimalsCarcinoma, Pancreatic DuctalCationic Amino Acid Transporter 1Cell Line, TumorCystathionine gamma-LyaseCysteineCystineGene DeletionHumansMiceMice, Mutant StrainsPancreatic NeoplasmsCationic Amino Acid Transporter 1Cystathionine gamma-LyaseCysteineCystineSlc7a1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.