Evidence map›Paper›PMID 32241942›Full record

ArticleScience (New York, N.Y.)2020

Maintenance of neural stem cell positional identity by

Ryan N Delgado, Benjamin Mansky, Sajad Hamid Ahanger, Changqing Lu, Rebecca E Andersen, Yali Dou, Arturo Alvarez-Buylla, Daniel A Lim

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Structural basis for the function of long noncoding RNAbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Epigenetic regulation in adult neural stem cells.Frontiers in cell and developmental biology · 2024
    Review
  10. Review
  11. Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Histological Studies of the Ventricular-Subventricular Zone as Neural Stem Cell and Glioma Stem Cell Niche.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021
    Review
  18. Article
  19. Article
  20. Ontogeny of adult neural stem cells in the mammalian brain.Current topics in developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ryan N DelgadoDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-7551-0182
Benjamin ManskyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-8652-0928
Sajad Hamid AhangerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-9531-6221
Changqing LuDepartment of Human Anatomy, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, P.R. China.
Rebecca E AndersenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0702-3120
Yali DouDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Arturo Alvarez-BuyllaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-4426-8925
Daniel A LimDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. daniel.lim@ucsf.edu.ORCID 0000-0001-7221-3425
University of California, San Francisco · USSan Francisco VA Medical Center · USUniversity of Michigan · USWest China Medical Center of Sichuan University · CN

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
NEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
Chromatin-based cellular memory in neural stem cellsDP2OD006505 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2009 to 2009
$2.3M
Long noncoding RNA regulation of neural stem cellsR01NS091544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2016 to 2020
$1.7M
Role of MLL Chromatin Remodeling Factor in Neural Stem CellsI01BX000252 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI DANIEL A LIM · 2009 to 2026
–
BLRD VA I01 BX000252NICHD NIH HHS T32 HD007470NIGMS NIH HHS T32 GM007618NIH HHS DP2 OD006505NINDS NIH HHS R01 NS028478NINDS NIH HHS R01 NS091544
6 · The paper itself

Abstract

Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences are maintained as the forebrain grows much larger and more anatomically complex. We found that the maintenance of NSC positional identity in the murine brain requires a

Indexed as

Genomic ImprintingAnimalsHedgehog ProteinsHistone-Lysine N-MethyltransferaseMiceMice, Mutant StrainsMyeloid-Lymphoid Leukemia ProteinNeural Stem CellsNeurogenesisProsencephalonThyroid Nuclear Factor 1TranscriptomeHedgehog ProteinsHistone-Lysine N-MethyltransferaseKmt2a protein, mouseMyeloid-Lymphoid Leukemia ProteinNkx2-1 protein, mouseShh protein, mouseThyroid Nuclear Factor 1

Identifiers

PMID32241942
PMCPMC7871661
OpenAlexW3014923780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.