Evidence map›Paper›PMID 32241918›Full record

ArticleThe Journal of biological chemistry2020

Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation-inert complex.

Cecilia Wallin, Jüri Jarvet, Henrik Biverstål, Sebastian Wärmländer, Jens Danielsson, Astrid Gräslund, Axel Abelein

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 39 citations in OpenAlex.

  1. Heterotrimetallic Au@CuMaterials today. Bio · 2026
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  6. Characterization of Uranyl (UOACS chemical neuroscience · 2023
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  9. An Extremely Stable Interprotein Tetrahedral Hg(Cys)Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  10. Molecular details of aluminium-amyloid β peptide interaction by nuclear magnetic resonance.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Article
  11. Review
  12. Metals in ALS TDP-43 Pathology.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Cecilia WallinDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, 106 91 Stockholm, Sweden.
Jüri JarvetDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, 106 91 Stockholm, Sweden.
Henrik BiverstålDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 141 52 Huddinge, Sweden; Department of Physical Organic Chemistry, Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia.
Sebastian WärmländerDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, 106 91 Stockholm, Sweden.
Jens DanielssonDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, 106 91 Stockholm, Sweden.
Astrid GräslundDepartment of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, 106 91 Stockholm, Sweden.
Axel AbeleinDepartment of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 141 52 Huddinge, Sweden. Electronic address: axel.abelein@ki.se.
Stockholm University · SEKarolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A detailed understanding of the molecular pathways for amyloid-β (Aβ) peptide aggregation from monomers into amyloid fibrils, a hallmark of Alzheimer's disease, is crucial for the development of diagnostic and therapeutic strategies. We investigate the molecular details of peptide fibrillization

Indexed as

Protein AggregatesAlzheimer DiseaseAmyloid beta-PeptidesHumansMetalsProtein BindingProtein DomainsAmyloid beta-PeptidesMetalsProtein AggregatesAlzheimer diseaseamyloidamyloid-beta (AB)metalmetal ion-protein interactionmonovalent ionneurodegenerationnuclear magnetic resonance (NMR)protein aggregationsilverzinc

Identifiers

PMID32241918
PMCPMC7247290
OpenAlexW3015119708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.