Evidence map›Paper›PMID 32241904›Full record

Observational studyGut2020

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents.

Xifan Wang, Songtao Yang, Shenghui Li, Liang Zhao, Yanling Hao, Junjie Qin, Lian Zhang, Chengying Zhang, Weijing Bian, Li Zuo and 34 more

2 registry-linked trialsOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Gut, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 361 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
361citing papers in PubMed, 7 pooled it
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03010696 completednot on this map

The Correlation Between Gut Microbiome/Metabolite and End Stage Renal Disease (ESRD)

TypeobservationalSponsorChina Agricultural UniversityRan2015 to 2017Enrolled293ConditionsKidney Failure, ChronicArmsNo interventions, questionnaire, collect specimen
NCT06877585 completednot on this mapstarted 2025, after this paper: background citation

Association Between Fecal Microbiota Composition, Metabolite Concentrations, and Indoxyl Sulfate Levels in Hemodialysis Patients

Typeobservational_patient_registrySponsorTungs' Taichung Metroharbour HospitalRan2025 to 2025Enrolled58ConditionsDysbiosis
3 · Its place in the literature

Who cites it

361 citing papers in PubMed, 7 syntheses or guidelines pooled it, 541 citations in OpenAlex.

  1. Pooled it
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  8. Gut microbes · 2026
    Trial
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  11. Article
  12. Review
  13. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
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301 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 15 institutions in 7 countries.

Xifan Wang *Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Songtao Yang *Department of Nephrology, Aerospace Center Hospital, Beijing, China.
Shenghui Li *Promegene Institute, Shenzhen, China.
Liang Zhao *Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Yanling HaoBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Junjie QinPromegene Institute, Shenzhen, China.
Lian ZhangDepartment of Epidemiology, School of Oncology, Beijing University, Beijing, China.
Chengying ZhangDepartment of Nephrology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China.
Weijing BianRenal Division, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
Li ZuoDepartment of Nephrology, Peking University People's Hospital, Beijing, China.
Xiu GaoDepartment of Nephrology, Peking University Shougang Hospital, Beijing, China.
Baoli ZhuInstitute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Xin Gen LeiDepartment of Animal Science, Cornell University, Ithaca, New York, USA.
Zhenglong GuDivision of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
Wei CuiInstitute of Reproductive and Developmental Biology, Imperial College London, London, UK.
Xiping XuBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Zhiming LiPromegene Institute, Shenzhen, China.
Benzhong ZhuBeijing Laboratory of Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Yuan LiBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Shangwu ChenKey Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Huiyuan GuoKey Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Hao ZhangBeijing Laboratory of Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Jing SunDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
Ming ZhangSchool of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China.
Yan HuiBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID 0000-0002-2388-131X
Xiaolin ZhangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Xiaoxue LiuBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Bowen SunBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Longjiao WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Qinglu QiuBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Yuchan ZhangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Xingqi LiKey Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Weiqian LiuBeijing Laboratory of Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Rui XueShanghai SLAC Laboratory Animal Co., Ltd, Shanghai Laboratory Animal Center, Shanghai, China.
Hong WuDepartment of Nephrology, Aerospace Center Hospital, Beijing, China.
DongHua ShaoDepartment of Nephrology, Aerospace Center Hospital, Beijing, China.
Junling LiDepartment of Nephrology, Peking University Shougang Hospital, Beijing, China.
Yuanjie ZhouPromegene Institute, Shenzhen, China.
Shaochuan LiPromegene Institute, Shenzhen, China.
Rentao YangPromegene Institute, Shenzhen, China.
Oluf Borbye PedersenNovo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences, Kobenhavns Universitet, Kobenhavn, Denmark.
Zhengquan YuBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China stanislav.ehrlich@inra.fr renfazheng@cau.edu.cn zyu@cau.edu.cn.ORCID 0000-0001-8696-2013
Stanislav Dusko EhrlichMetagenopolis, Université Paris-Saclay, INRAE, MGP, 78350, Jouy-en-Josas, France stanislav.ehrlich@inra.fr renfazheng@cau.edu.cn zyu@cau.edu.cn.ORCID 0000-0002-7563-4046
Fazheng RenBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China stanislav.ehrlich@inra.fr renfazheng@cau.edu.cn zyu@cau.edu.cn.
China Agricultural University · CNAerospace Center Hospital · CNChinese Academy of Sciences · CNCornell University · USPeking University · CNPeking University Shougang Hospital · CNUniversity of Copenhagen · DKAgrobiotechnology Institute · ESBeijing Technology and Business University · CNCapital University · USChinese PLA General Hospital · CNImperial College London · GBKing's College London · GBNanfang Hospital · CNShanghai Model Organisms (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and renal failure symptoms in human end-stage renal disease (ESRD).

designCharacterisation of gut microbiome, serum and faecal metabolome and human phenotypes in a cohort of 223 patients with ESRD and 69 healthy controls. Multidimensional data integration to reveal links between these datasets and the use of chronic kidney disease (CKD) rodent models to test the effects of intestinal microbiome on toxin accumulation and disease severity.

resultsA group of microbial species enriched in ESRD correlates tightly to patient clinical variables and encode functions involved in toxin and secondary bile acids synthesis; the relative abundance of the microbial functions correlates with the serum or faecal concentrations of these metabolites. Microbiota from patients transplanted to renal injured germ-free mice or antibiotic-treated rats induce higher production of serum uraemic toxins and aggravated renal fibrosis and oxidative stress more than microbiota from controls. Two of the species,

conclusionAberrant gut microbiota in patients with ESRD sculpts a detrimental metabolome aggravating clinical outcomes, suggesting that the gut microbiota will be a promising target for diminishing uraemic toxicity in those patients. TRIAL REGISTRATION NUMBER: This study was registered at ClinicalTrials.gov (NCT03010696).

Indexed as

Gastrointestinal MicrobiomeMetabolomeAnimalsBile Acids and SaltsCase-Control StudiesDisease Models, AnimalFecesFemaleHumansKidney Failure, ChronicMaleMiceOxidative StressRatsToxins, BiologicalUremiaBile Acids and SaltsToxins, Biologicalbile acidenteric bacterial microflora

Identifiers

PMID32241904
PMCPMC7677483
OpenAlexW3014637289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.