ArticleGut2021
Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study.
Article in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 7 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- The Impact of Artificial Intelligence-Assisted Endoscopy on the Detection of Upper Gastrointestinal Neoplasms: A Systematic Review and Meta-Analyses.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Pooled it
- Upper gastrointestinal endoscopic screening uptake and associated factors in East Asia: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries-A Systematic Review and Meta-Analysis.United European gastroenterology journal · 2025Pooled it
- Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.Cancer medicine · 2023Pooled it
- Profiles and Findings of Population-Based Esophageal Cancer Screening With Endoscopy in China: Systematic Review and Meta-analysis.JMIR public health and surveillance · 2023Pooled it
- Pooled it
- Risk Prediction Model for Esophageal Cancer Among General Population: A Systematic Review.Frontiers in public health · 2021Pooled it
- Effect of endoscopic screening for non-cardia gastric cancer: a 12-year report of a population-based randomized trial.BMC medicine · 2026Trial
- Opening the black box: defining true-negative outcomes in esophageal cancer screening - a population-based study.BMC medicine · 2025Trial
- Development and usability evaluation of a patient journey-based mHealth intervention for esophageal cancer patients: a three-phase protocol.Frontiers in public health · 2025Trial
- Influences of Propofol, Ciprofol and Remimazolam on Dreaming During Anesthesia for Gastrointestinal Endoscopy: A Randomized Double-Blind Parallel-Design Trial.Drug design, development and therapy · 2024Trial
- Initial results from a multi-center population-based cluster randomized trial of esophageal and gastric cancer screening in China.BMC gastroenterology · 2020Trial
- Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Review
- Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence.Nature medicine · 2026Article
- Hybrid endoscopic submucosal dissection reduces procedure time for superficial esophageal squamous carcinomas ≤ 2 cm: a single-center retrospective propensity score-matched analysis.Surgical endoscopy · 2026Article
- Cancer burden and control in China: landscape, trends and challenges.Nature reviews. Clinical oncology · 2026Review
- Comparative validation and local adaptation of gastric cancer risk assessment models in a large multicenter endoscopic screening cohort in China.BMC medicine · 2026Article
- Optimizing risk cutoffs in joint endoscopic screening for upper gastrointestinal cancers: a data-driven approach from models to real-world practice.Surgical endoscopy · 2026Article
- Plasma proteomic signatures improve risk stratification and personalized screening for gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- To dye or not to dye? Comparing real-world diagnostic performance of white light, electronic, and Lugol's chromoendoscopy for esophageal squamous neoplasia.Surgical endoscopy · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo estimate the effectiveness of endoscopic screening programme in reducing incidence and mortality of upper gastrointestinal cancer in high risks areas of China.
designThis multicentre population-based cohort study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40 to 69 years were identified as target subjects. We refer to those who were invited for screening collectively as the invited group. Of these, we classify those who were invited and undertook endoscopic screening as the screened group and those who were invited but did not accept screening as the non-screened group. Target subjects who were not invited to the screening were assigned to the control group. The effectiveness of the endoscopic screening and screening programme were evaluated by comparing reductions in incidence and mortality from upper gastrointestinal cancer in the screened and invited group with control group.
resultsOur cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, upper gastrointestinal cancer incidence and mortality decreased by 23% (relative risk (RR)=0.77, 95% CI 0.74 to 0.81) and 57% (RR=0.43, 95% CI 0.40 to 0.47) in the screened group, respectively, and by 14% (RR=0.86, 95% CI 0.84 to 0.89) and 31% (RR=0.69, 95% CI 0.66 to 0.72) in the invited group, respectively.
conclusionAmong individuals aged 40 to 69 years in high risk areas of upper gastrointestinal cancer, one-time endoscopic screening programme was associated with a significant decrease in upper gastrointestinal cancer incidence and mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.