Evidence map›Paper›PMID 32241898›Full record

Trial reportGut2021

Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging.

Naohiro Yoshida, Hisashi Doyama, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Yoshinobu Yamamoto, Naomi Kakushima, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao and 7 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Review
  9. Observational
  10. Review
  11. Article
  12. Review
  13. Early detection of gastrointestinal cancers in low- and middle-income countries: A risk-stratified framework and implementation roadmap.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  14. [Bottlenecks and breakthroughs in gastric cancer diagnosis and treatment: Towards a new era of precision and intelligent integration].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Review
  15. Review
  16. Article
  17. Prevention of Gastric Cancer.Medicina (Kaunas, Lithuania) · 2026
    Review
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 14 institutions in 1 country.

Naohiro YoshidaDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Ishikawa, Japan.ORCID 0000-0002-7867-8490
Hisashi DoyamaDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Ishikawa, Japan.
Tomonori YanoDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
Takahiro HorimatsuDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Noriya UedoDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Yoshinobu YamamotoDepartment of Gastrointestinal Oncology, Hyogo Cancer Center, Hyogo, Japan.
Naomi KakushimaDepartment of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Hiromitsu KanzakiDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Shinichiro HoriDepartment of Endoscopy, National Hospital Organization Shikoku Cancer Center, Ehime, Japan.
Kenshi YaoDepartment of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Ichiro OdaDepartment of Endoscopy, National Cancer Center Hospital, Tokyo, Japan.
Chikatoshi KatadaDepartment of Gastroenterology, Kitasato University School of Medicine, Kanagawa, Japan.
Chizu YokoiDepartment of Gastroenterology, National Center for Global Health and Medicine, Tokyo, Japan.
Ken OhataDepartment of Gastroenterology, NTT Medical Center Tokyo, Tokyo, Japan.
Kenichi YoshimuraInnovative Clinical Research Center, Kanazawa University Hospital, Ishikawa, Japan.
Hideki IshikawaDepartment of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Manabu MutoDepartment of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan mmuto@kuhp.kyoto-u.ac.jp.
Ishikawa Prefectural Central Hospital · JPKyoto University · JPFukuoka University · JPHyogo Prefectural Cancer Center · JPKanazawa University Hospital · JPKitasato University · JPKyoto Prefectural University of Medicine · JPNational Cancer Center Hospital East · JPNational Center for Global Health and Medicine · JPNTT Medical Center · JPOkayama University · JPOsaka International Cancer Institute · JPShikoku Cancer Center · JPShizuoka Cancer Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEarly detection of gastric cancer has been the topic of major efforts in high prevalence areas. Whether advanced imaging methods, such as second-generation narrow band imaging (2G-NBI) can improve early detection, is unknown.

designThis open-label, randomised, controlled tandem trial was conducted in 13 hospitals. Patients at increased risk for gastric cancer were randomly assigned to primary white light imaging (WLI) followed by secondary 2G-NBI (WLI group: n=2258) and primary 2G-NBI followed by secondary WLI (2G-NBI group: n=2265) performed by the same examiner. Suspected early gastric cancer (EGC) lesions in both groups were biopsied. Primary endpoint was the rate of EGC patients in the primary examination. The main secondary endpoint was the positive predictive value (PPV) for EGC in suspicious lesions detected (primary examination).

resultsEGCs were found in 44 (1.9%) and 53 (2.3%; p=0.412) patients in the WLI and 2G-NBI groups, respectively, during primary EGD. In a post hoc analysis, the overall rate of lesions detected at the second examination was 25% (n=36/145), with no significant differences between groups. PPV for EGC in suspicious lesions was 13.5% and 20.9% in the WLI (50/371 target lesions) and 2G-NBI groups (59/282 target lesions), respectively (p=0.015).

conclusionThe overall sensitivity of primary endoscopy for the detection of EGC in high-risk patients was only 75% and should be improved. 2G-NBI did not increase EGC detection rate over conventional WLI. The impact of a slightly better PPV of 2G-NBI has to be evaluated further. TRIAL REGISTRATION NUMBER: UMIN000014503.

Indexed as

Early Detection of CancerEndoscopyNarrow Band ImagingAdultAgedAged, 80 and overFemaleHumansJapanMaleMiddle AgedPredictive Value of TestsStomach NeoplasmsYoung Adultendoscopygastric cancerscreeningsurveillance

Identifiers

PMID32241898
PMCPMC7788198
OpenAlexW3015025173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.