Evidence map›Paper›PMID 32241582›Full record

ArticleNeurobiology of aging2020

Contingency awareness, aging, and the parietal lobe.

Dominic T Cheng, Alyssa M Katzenelson, Monica L Faulkner, John F Disterhoft, John M Power, John E Desmond

Abstract read
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In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dominic T ChengDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychology, Auburn University, Auburn, AL, USA. Electronic address: dominic.cheng@gmail.com.
Alyssa M KatzenelsonDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Monica L FaulknerDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John F DisterhoftDepartment of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
John M PowerDepartment of Physiology, University of New South Wales, Sydney, NSW, Australia.
John E DesmondDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
fMRI Analysis of Aging and Awareness in ConditioningR01AG021501 · NIA · STANFORD UNIVERSITY · PI DESMOND, JOHN E · 2004 to 2008
$1.6M
Neuroimaging of Eyeblink Conditioning in Subjects with Alcohol Use DisordersK01AA020873 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI CHENG, DOMINIC T · 2011 to 2015
$614k
NIAAA NIH HHS K01 AA020873NIA NIH HHS R01 AG021501NIH HHS S10 OD021648
6 · The paper itself

Abstract

Contingency awareness is thought to rely on an intact medial temporal lobe and also appears to be a function of age, as older subjects tend to be less aware. The current investigation used functional magnetic resonance imaging, transcranial direct current stimulation, and eyeblink classical conditioning to study brain processes related to contingency awareness as a function of age. Older adults were significantly less aware of the relationship between the tone-airpuff pairings than younger adults. Greater right parietal functional magnetic resonance imaging activation was associated with higher levels of contingency awareness for younger and older subjects. Cathodal transcranial direct current stimulation over the right parietal lobe led to lower levels of awareness in younger subjects without disrupting conditioned responses. Older adults exhibited hyperactivations in the parietal and medial temporal lobes, despite showing no conditioning deficits. These findings strongly support the idea that the parietal cortex serves as a substrate for contingency awareness and that age-related disruption of this region is sufficient to impair awareness, which may be a manifestation of some form of naturally occurring age-related neglect.

Indexed as

AdultAgedAgingAwarenessBlinkingConditioning, ClassicalFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParietal LobeTemporal LobeTranscranial Direct Current StimulationYoung AdultClassical conditioningConsciousnessfMRIMemorytDCS

Identifiers

PMID32241582
PMCPMC7953809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.