Evidence map›Paper›PMID 32241557›Full record

ArticleDental materials : official publication of the Academy of Dental Materials2020

Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive.

Sara Kalagi, Sabrina A Feitosa, Eliseu A Münchow, Victor M Martins, Ashley E Karczewski, N Blaine Cook, Kim Diefenderfer, George J Eckert, Saulo Geraldeli, Marco C Bottino

Abstract read
In one paragraph

Article in Dental materials : official publication of the Academy of Dental Materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025
    Review
  3. Article
  4. Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications.Dental materials : official publication of the Academy of Dental Materials · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara KalagiDepartment of Cariology, Operative Dentistry & Dental Public Health, Indiana University School of Dentistry (IUSD), Indianapolis, IN, USA; Department of Restorative Dental Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Sabrina A FeitosaDepartment of Biomedical and Applied Sciences, Division of Dental Biomaterials, IUSD, Indianapolis, IN, USA.
Eliseu A MünchowDepartment of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil.
Victor M MartinsDepartment of Biomedical and Applied Sciences, Division of Dental Biomaterials, IUSD, Indianapolis, IN, USA.
Ashley E KarczewskiDepartment of Biomedical and Applied Sciences, Division of Dental Biomaterials, IUSD, Indianapolis, IN, USA.
N Blaine CookDepartment of Cariology, Operative Dentistry & Dental Public Health, Indiana University School of Dentistry (IUSD), Indianapolis, IN, USA.
Kim DiefenderferDepartment of Cariology, Operative Dentistry & Dental Public Health, Indiana University School of Dentistry (IUSD), Indianapolis, IN, USA.
George J EckertDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Saulo GeraldeliDepartment of General Dentistry, School of Dental Medicine, East Carolina University, Greenville, NC, USA.
Marco C BottinoDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA. Electronic address: mbottino@umich.edu.

Funding

NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHESR01DE026578 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2017 to 2021
$1.7M
A Novel Multilayered Membrane for Periodontal RegenerationK08DE023552 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2013 to 2017
$716k
NIDCR NIH HHS K08 DE023552NIDCR NIH HHS R01 DE026578
6 · The paper itself

Abstract

objectivesThe purpose of this study was to synthesize chlorhexidine (CHX)-encapsulated aluminosilicate clay nanotubes (Halloysite®, HNTs) and to incorporate them into the primer/adhesive components of an etch-and-rinse adhesive system (SBMP; Scotchbond Multipurpose, 3M ESPE) and to test their effects on degree of conversion, viscosity, immediate and long-term bonding to dentin.

methodsCHX-modified HNTs were synthesized using 10% or 20% CHX solutions. The primer and the adhesive components of SBMP were incorporated with 15wt.% of the CHX-encapsulated HNTs. Degree of conversion (DC) and viscosity analyses were performed to characterize the modified primers/adhesives. For bond strength testing, acid-etched dentin was treated with one of the following: SBMP (control); 0.2%CHX solution before SBMP; CHX-modified primers+SBMP adhesive; SBMP primer+CHX-modified adhesives; and SBMP primer+CHX-free HNT-modified adhesive. The microtensile bond strength test was performed after immediate (24h) and long-term (6 months) of water storage. Data were analyzed using ANOVA and Tukey (α=5%) and the Weibull analysis.

resultsDC was greater for the CHX-free HNT-modified adhesive, whereas the other experimental adhesives showed similar DC as compared with the control. Primers were less viscous than the adhesives, without significant differences within the respective materials. At 24h, all groups showed similar bonding performance and structural reliability; whereas at the 6-month period, groups treated with the 0.2%CHX solution prior bonding or with the CHX-modified primers resulted in greater bond strength than the control and superior reliability. SIGNIFICANCE: The modification of a primer or adhesive with CHX-encapsulated HNTs was an advantageous approach that did not impair the polymerization, viscosity and bonding performance of the materials, showing a promising long-term effect on resin-dentin bonds.

Indexed as

Dental BondingNanotubesChlorhexidineDentinDentin-Bonding AgentsMaterials TestingMicroscopy, Electron, ScanningPolymerizationReproducibility of ResultsResin CementsSurface PropertiesTensile StrengthChlorhexidineDentin-Bonding AgentsResin CementsAdhesivesAluminosilicate clayBondingDentinHalloysiteMicrotensileNanotube

Identifiers

PMID32241557
PMCPMC7224330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.