ReviewAdvances in cancer research2020
Patient barriers to cancer clinical trial participation and navigator activities to assist.
Review in Advances in cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Challenges and Approaches to Recruitment for and Retention in a Dyad-Focused eHealth Intervention During COVID-19: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Implementation of postpartum navigation for low-income individuals at an urban academic medical center.PloS one · 2023Trial
- Development and initial validation of a scale assessing sources of decision hesitation in patients with lung cancer invited to participate in drug clinical trials.Asia-Pacific journal of oncology nursing · 2026Article
- Barrier resolution via patient navigation in the context of cancer care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Perceptions of health research participation in rural and urban Pennsylvanians.Journal of clinical and translational science · 2026Article
- Article
- Patient perspectives on participation in the Danish Breast Cancer Group Proton Trial: A qualitative research study.Technical innovations & patient support in radiation oncology · 2025Review
- Enrollment Patterns and Site-Level Predictors of Black Participant Recruitment to a Multisite Randomized Cancer Clinical Trial.JCO oncology advances · 2025Article
- Clinical trial knowledge, discussion, and participation among cancer survivors: A HINTS-SEER study.Patient education and counseling · 2025Article
- Racial Differences in ctDNA Profiles, Targeted Therapy Use, and Outcomes in Metastatic Breast Cancer.JAMA network open · 2025Article
- Qualitative Study of Health Care Professional Perspectives on Recruiting Minority Patients in Cancer Trials.Health equity · 2025Article
- Social Marketing Perspective on Participant Recruitment in Informatics-Based Intervention Studies.AIDS and behavior · 2024Article
- Breast cancer clinical trial participation among diverse patients at a comprehensive cancer center.NPJ breast cancer · 2024Article
- Promoting equity in clinical research: The role of social determinants of health.Journal of biomedical informatics · 2024Article
- What Is Ailing Oncology Clinical Trials? Can We Fix Them?Current oncology (Toronto, Ont.) · 2024Review
- Primary care patient interests in joining a planned multi-cancer early detection clinical trial.Cancer medicine · 2024Article
- Addressing transportation barriers in oncology: existing programs and new solutions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Trial staff and community member perceptions of barriers and solutions to improving racial and ethnic diversity in clinical trial participation; a mixed method study.Contemporary clinical trials communications · 2024Article
- Addressing disparities in cancer clinical trials: a roadmap to more equitable accrual.Frontiers in health services · 2024Article
- Exploring Factors Affecting Acceptance of Fecal Microbiota Transplantation for Patients with Recurrent Urinary Tract Infections: a Descriptive Qualitative Study.Patient preference and adherence · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Clinical research is vital to the discovery of new cancer treatments that can enhance health and prolong life for cancer patients, but breakthroughs in cancer treatment are limited by challenges recruiting patients into cancer clinical trials (CT). Only 3-5% of cancer patients in the United States participate in a cancer CT and there are disparities in CT participation by age, race and gender. Strategies such as patient navigation, which is designed to provide patients with education and practical support, may help to overcome challenges of CT recruitment. The current study evaluated an intervention in which lay navigators were utilized to provide patient education and practical support for helping patients overcome barriers to CT participation and related clinical care. A patient barrier checklist was utilized to record patient barriers to CT participation and care, actions taken by navigators to assist patients with these barriers, and whether or not these barriers could be overcome. Forty patients received patient navigation services. The most common barriers faced by navigated patients were fear (n=9), issues communicating with medical personnel (n=9), insurance issues (n=8), transportation difficulties (n=6) and perceptions about providers and treatment (n=4). The most common activities undertaken by navigators were making referrals and contacts on behalf of patients (e.g., support services, family, clinicians; n=25). Navigators also made arrangement for transportation, financial, medication and equipment services for patients (n=11) and proactively navigated patients (n=8). Barriers that were not overcome for two or more patients included insurance issues, lack of temporary housing resources for patients in treatment and assistance with household bills. The wide array of patient barriers to CT participation and navigator assistance documented in this study supports the CT navigator role in facilitating quality care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.