Evidence map›Paper›PMID 32241289›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2020

Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload.

Eric D Carruth, Irvin Teh, Jurgen E Schneider, Andrew D McCulloch, Jeffrey H Omens, Lawrence R Frank

Open access · goldAbstract readComparative Study

PubMed Full text at PMC Publisher

In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

1.0field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium.American journal of physiology. Heart and circulatory physiology · 2025
Article
Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging.Basic research in cardiology · 2025
Article
Cardiovascular magnetic resonance imaging for sequential assessment of cardiac fibrosis in mice: technical advancements and reverse translation.American journal of physiology. Heart and circulatory physiology · 2024
Review
Contribution of atrial myofiber architecture to atrial fibrillation.PloS one · 2023
Article
Towards a Whole Sample Imaging Approach Using Diffusion Tensor Imaging to Examine the Foreign Body Response to Explanted Medical Devices.Polymers · 2022
Article
Myocardial mesostructure and mesofunction.American journal of physiology. Heart and circulatory physiology · 2022
Review
Recreating the heart's helical structure-function relationship with focused rotary jet spinning.Science (New York, N.Y.) · 2022
Article
Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction.Bioactive materials · 2021
Review
Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography.Scientific reports · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Eric D CarruthDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.

Irvin TehLeeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, UK.

Jurgen E SchneiderLeeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, UK.

Andrew D McCullochDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.

Jeffrey H OmensDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA. jomens@ucsd.edu.

Lawrence R FrankDepartment of Radiology, University of California San Diego, La Jolla, California, USA.

University of California, San Diego · USUniversity of Leeds · GB

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R., MACLEOD, ROB S. · 2012 to 2019

$9.7M

Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026

$7.3M

The Cardiac Atlas ProjectR01HL121754 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D., OMENS, JEFFREY H. · 2014 to 2023

$5.0M

Systems Biology of Hypertrophic Heart Disease from Molecular Pathways to Organ SystemR01HL137100 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D. · 2017 to 2020

$2.0M

Diffusion Imaging in Gray MatterR01MH096100 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FRANK, LAWRENCE R · 2012 to 2016

$1.9M

NHLBI NIH HHS R01 HL121754NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL137100NIGMS NIH HHS P41 GM103545NIMH NIH HHS R01 MH096100

6 · The paper itself

Abstract

backgroundPressure overload left ventricular (LV) hypertrophy is characterized by increased cardiomyocyte width and ventricle wall thickness, however the regional variation of this remodeling is unclear. Cardiovascular magnetic resonance (CMR) diffusion tensor imaging (DTI) may provide a non-invasive, comprehensive, and geometrically accurate method to detect regional differences in structural remodeling in hypertrophy. We hypothesized that DTI parameters, such as fractional and planar anisotropy, would reflect myocyte remodeling due to pressure overload in a regionally-dependent manner.

methodsWe investigated the regional distributions of myocyte remodeling in rats with or without transverse aortic constriction (TAC) via direct measurement of myocyte dimensions with confocal imaging of thick tissue sections, and correlated myocyte cross-sectional area and other geometric features with parameters of diffusivity from ex-vivo DTI in the same regions of the same hearts.

resultsWe observed regional differences in several parameters from DTI between TAC hearts and SHAM controls. Consistent with previous studies, helix angles from DTI correlated strongly with those measured directly from histological sections (p < 0.001, R

conclusionsThese results show that structural remodeling in pressure overload LV hypertrophy is regionally heterogeneous, especially transmurally, with a greater degree of remodeling in the sub-endocardium compared to the sub-epicardium. Additionally, several parameters derived from DTI correlated significantly with measurements of myocyte geometry from direct measurement in histological sections. We suggest that DTI may provide a non-invasive, comprehensive method to detect regional structural myocyte LV remodeling during disease.

Indexed as

Cell SizeDiffusion Tensor ImagingVentricular Function, LeftVentricular PressureVentricular RemodelingAnimalsDisease Models, AnimalHypertrophy, Left VentricularMaleMyocytes, CardiacPredictive Value of TestsRats, Sprague-DawleyDiffusion tensor imagingMyocyte remodelingPressure overload hypertrophyTransmural gradient

Identifiers

PMID32241289

DOI10.1186/s12968-020-00615-1

PMCPMC7114814

OpenAlexW3014299840

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.