Evidence map›Paper›PMID 32241200›Full record

ArticleJournal of biological rhythms2020

The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene

Joseph R Knoedler, José Ávila-Mendoza, Arasakumar Subramani, Robert J Denver

Open access · greenAbstract read
In one paragraph

Article in Journal of biological rhythms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph R KnoedlerNeuroscience Graduate Program, The University of Michigan, Ann Arbor, Michigan.
José Ávila-MendozaDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan.
Arasakumar SubramaniDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan.
Robert J DenverNeuroscience Graduate Program, The University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-2773-8174
University of Michigan · US

Funding

Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
Hormone and Activity-Dependent Neural Gene ExpressionR01NS046690 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENVER, ROBERT J · 2004 to 2007
$815k
Thyroid hormone regulates DNA methylation in the developing brain through direct modulation of the DNA methyltransferase 3a geneR21NS088062 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENVER, ROBERT J · 2015 to 2016
$412k
NICHD NIH HHS T32 HD079342NINDS NIH HHS R01 NS046690NINDS NIH HHS R21 NS088062
6 · The paper itself

Abstract

An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modulate transcription of the clock-output gene

Indexed as

AnimalsCell Cycle ProteinsCell LineCircadian ClocksCircadian RhythmCLOCK ProteinsCRISPR-Cas SystemsDNA-Binding ProteinsGene Expression RegulationGene Knockout TechniquesKruppel-Like Transcription FactorsMaleMiceMice, KnockoutRepressor ProteinsTranscription FactorsCell Cycle ProteinsCLOCK ProteinsDbp protein, mouseDNA-Binding ProteinsKlf13 protein, mouseKlf9 protein, mouseKruppel-Like Transcription FactorsRepressor ProteinsTranscription Factorscircadian clockclock outputDbpglucocorticoidKrüppel-like factortranscription

Identifiers

PMID32241200
PMCPMC9199006
OpenAlexW3014948489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.