Global optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats.

Marina V Evans, Christopher R Eklund, David N Williams, Yusupha M Sey, Jane Ellen Simmons

Open access · greenAbstract read

In one paragraph

Article in Inhalation toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 48% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Mathematical modeling of regulatory networks of intracellular processes - Aims and selected methods.Computational and structural biotechnology journal · 2023
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marina V EvansORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA.

Christopher R EklundORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA.

David N WilliamsORISE, Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.

Yusupha M SeyORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA.

Jane Ellen SimmonsORD, National Health and Environmental Effects Research Laboratory, ISTD, US Environmental Protection Agency, Research Triangle Park, NC, USA.

Research Triangle Park Foundation · USEnvironmental Protection Agency · USOak Ridge Institute for Science and Education

Funding

Intramural EPA EPA999999

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, BiologicalAdipose TissueAdministration, InhalationAnimalsChloroformComputer SimulationKidneyLiverMaleMusclesRats, Inbred F344ChloroformchloroformMichaelis–Menten equationnumerical optimizationoptimizationPhysiologically based pharmacokinetic (PBPK) model

Identifiers

PMID32241199

DOI10.1080/08958378.2020.1742818

PMCPMC8115211

OpenAlexW3014628202

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.