ArticlePediatric research2020
Family integrated care in single family rooms for preterm infants and late-onset sepsis: a retrospective study and mediation analysis.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The effects of the introduction of the single-family room in neonatal and paediatric intensive care on the outcomes of paediatric patients, families, staff, and organizations: a mixed method systematic review.BMC health services research · 2025Pooled it
- Pooled it
- The effect of family integrated care on the prognosis of premature infants.BMC pediatrics · 2022Trial
- Summary of best evidence on parental involvement in neonatal intensive care units: integrating family-centered and family-integrated care models.Global health action · 2026Review
- Stable Trends in Clinical Outcomes Before Introduction of Couplet Care in a Danish Neonatal Intensive Care Unit.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Developmental care for preterm infants: a scoping review of interventions, outcomes, and implementation contexts.Frontiers in pediatrics · 2026Review
- "More than medical care": a qualitative study on family support systems in the neonatal intensive care unit in Ghana.BMC pediatrics · 2025Article
- Review
- Short and mid-term neonatal outcomes in high-risk infants undergoing FICare: a case control study.Pediatric research · 2025Article
- Designing eHealth interventions for children with complex care needs requires continuous stakeholder collaboration and co-creation.PEC innovation · 2024Article
- Nutritional intake and growth until two years of age in moderate and late preterms.Pediatric research · 2024Article
- Article
- A unit's experience with hybrid NICU design: description of care model and implications for patients, families, and professionals.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Mother-newborn couplet care: Nordic country experiences of organization, models and practice.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Effect of family integrated care on breastfeeding of preterm infants: A scoping review.Nursing open · 2023Article
- Maternal mental health after infant discharge: a quasi-experimental clinical trial of family integrated care versus family-centered care for preterm infants in U.S. NICUs.BMC pediatrics · 2023Article
- Neonatal admission after lithium use in pregnant women with bipolar disorders: a retrospective cohort study.International journal of bipolar disorders · 2023Article
- Neonatal outcomes from a quasi-experimental clinical trial of Family Integrated Care versus Family-Centered Care for preterm infants in U.S. NICUs.BMC pediatrics · 2022Article
- Association of a Zero-Separation Neonatal Care Model With Stress in Mothers of Preterm Infants.JAMA network open · 2022Article
- Association of a Family Integrated Care Model With Paternal Mental Health Outcomes During Neonatal Hospitalization.JAMA network open · 2022Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring hospital stay after birth, preterm infants are susceptible to late-onset sepsis (LOS).
objectiveTo study the effect of family integrated care in single family rooms (SFRs) compared to standard care in open bay units (OBUs) on LOS. Peripheral or central venous catheters (PVCs/CVCs) and parenteral nutrition (PN) were investigated as potential mediators. Secondary outcomes were length of stay, exclusive breastfeeding at discharge, and weight gain during hospital stay.
methodsSingle-center retrospective before-after study with preterm infants admitted ≥3 days.
resultsWe studied 1,046 infants (468 in SFRs, 578 in OBUs, median gestational age 35 weeks). SFRs were associated with less LOS (adjusted odds ratio (OR) 0.486, 95% confidence interval (CI): 0.293; 0.807, p = 0.005). PVCs (indirect effect -1.757, 95% CI: -2.738; -1.068), CVCs (indirect effect -1.002, 95% CI: -2.481; 0.092), and PN (indirect effect -1.784, 95% CI: -2.688; -1.114) were possible mediators of the effect. PN was the main mediator of the effect of SFRs on LOS. We found shorter length of stay (median length of stay in SFRs 10 days and in OBUs 12 days, adjusted β -0.088, 95% CI: -0.159; -0.016, p = 0.016), but no differences in weight gain or exclusive breastfeeding at discharge.
conclusionsSFRs were associated with decreased incidences of LOS and shorter length of hospital stay. The positive effect of SFRs on LOS was mainly mediated through a decreased use of PN in SFRs. IMPACT: Family integrated care (FICare) in single family rooms for preterm infants was associated with less late-onset sepsis events during hospital stay and a shorter length of hospital stay after birth. FICare in single family rooms was associated with less use of peripheral or central venous catheters and parenteral nutrition. Mediation analysis provided insights into the mechanisms underlying the effect of FICare in single family rooms on late-onset sepsis and helped explain the differences observed in late-onset sepsis between FICare in single family rooms and open bay units. The reduction in late-onset sepsis in FICare in single family rooms was mediated by a reduced use of intravenous catheters and parenteral nutrition.
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