Evidence map›Paper›PMID 32240619›Full record

ArticleThe American journal of pathology2020

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4

Anuradha Krishnan, Tomohiro Katsumi, Maria E Guicciardi, Adiba I Azad, Nazli B Ozturk, Christy E Trussoni, Gregory J Gores

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Hepatic immune regulation and sex disparities.Nature reviews. Gastroenterology & hepatology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anuradha KrishnanDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Tomohiro KatsumiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Maria E GuicciardiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Adiba I AzadDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Nazli B OzturkDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Christy E TrussoniDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Gregory J GoresDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: gores.gregory@mayo.edu.
Mayo Clinic · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
Cholestatic Liver InjuryR01DK124182 · NIDDK · MAYO CLINIC ROCHESTER · PI GORES, GREGORY J. · 2020 to 2023
$1.4M
NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK124182
6 · The paper itself

Abstract

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic cholestatic liver disease is unclear. Herein, we examined TRAIL receptor signaling in a mouse model of cholestatic liver injury. TRAIL receptor-deficient (Tnsf10 or Tr

Indexed as

AnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCholestasisDisease Models, AnimalFemaleLiverLiver CirrhosisMacrophagesMaleMiceMice, KnockoutReceptors, TNF-Related Apoptosis-Inducing LigandSignal TransductionATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BReceptors, TNF-Related Apoptosis-Inducing Ligand

Identifiers

PMID32240619
PMCPMC7280758
OpenAlexW3015093464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.