Evidence map›Paper›PMID 32240530›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2020

Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics.

Vilakshan Alambyan, Jonathan Pace, Persen Sukpornchairak, Xin Yu, Hamza Alnimir, Ryan Tatton, Gautham Chitturu, Anisha Yarlagadda, Ciro Ramos-Estebanez

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Vilakshan AlambyanDepartment of Neurology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
Jonathan PaceNeurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Persen SukpornchairakNeurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Xin YuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Hamza AlnimirNeurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
Ryan TattonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Gautham ChitturuDepartment of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Anisha YarlagaddaDepartment of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Ciro Ramos-EstebanezNeurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA. cramoses@icloud.com.ORCID http://orcid.org/0000-0001-6737-5374

Funding

Phosphorus-31 MR Spectroscopic Imaging and FingerprintingR01EB023704 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI LIANG, ZHI-PEI, YU, XIN · 2017 to 2020
$1.8M
NIBIB NIH HHS R01 EB023704
6 · The paper itself

Abstract

Modern neurocritical care relies on ancillary diagnostic testing in the form of multimodal monitoring to address acute changes in the neurological homeostasis. Much of our armamentarium rests upon physiological and biochemical surrogates of organ or regional level metabolic activity, of which a great deal is invested at the metabolic-hemodynamic-hydrodynamic interface to rectify the traditional intermediaries of glucose consumption. Despite best efforts to detect cellular neuroenergetics, current modalities cannot appreciate the intricate coupling between astrocytes and neurons. Invasive monitoring is not without surgical complication, and noninvasive strategies do not provide an adequate spatial or temporal resolution. Without knowledge of the brain's versatile behavior in specific metabolic states (glycolytic vs oxidative), clinical practice would lag behind laboratory empiricism. Noninvasive metabolic imaging represents a new hope in delineating cellular, nigh molecular level energy exchange to guide targeted management in a diverse array of neuropathology.

Indexed as

BrainEnergy MetabolismHumansNeuroimagingBrain metabolismMetabolic imagingMRINeurocritical careNeuroenergeticsStroke

Identifiers

PMID32240530
PMCPMC7283376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.