ArticleAnnals of biomedical engineering2020
Displacement- and Strain-Based Discrimination of Head Injury Models across a Wide Range of Blunt Conditions.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- In silico investigation of brain tissue responses associated with mild blast traumatic brain injury.Frontiers in bioengineering and biotechnology · 2026Article
- Axonal tract-integrated finite element brain model for predicting mild traumatic brain injury based on axonal strain.Frontiers in bioengineering and biotechnology · 2026Article
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
- An MRI-derived head-neck finite element model.Biomechanics and modeling in mechanobiology · 2025Article
- Average Responses of Brain Displacement Under Rotational Loading for Computational Model Validation.IEEE transactions on bio-medical engineering · 2025Article
- On-field Head Acceleration Exposure Measurement Using Instrumented Mouthguards: Missing Data Imputation for Complete Exposure Analysis.Annals of biomedical engineering · 2025Article
- An Evaluation of Tentorium and Brainstem Influences on Intracranial Displacements and Strains.Annals of biomedical engineering · 2025Article
- Article
- Brain Material Properties and Integration of Arachnoid Complex for Biofidelic Impact Response for Human Head Finite Element Model.Annals of biomedical engineering · 2024Article
- Effect of Direction and Frequency of Skull Motion on Mechanical Vulnerability of the Human Brain.Journal of biomechanical engineering · 2023Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- Real-time dynamic simulation for highly accurate spatiotemporal brain deformation from impact.Computer methods in applied mechanics and engineering · 2022Article
- Cerebral vascular strains in dynamic head impact using an upgraded model with brain material property heterogeneity.Journal of the mechanical behavior of biomedical materials · 2022Article
- Displacement voxelization to resolve mesh-image mismatch: Application in deriving dense white matter fiber strains.Computer methods and programs in biomedicine · 2022Article
- Displacement Error Propagation From Embedded Markers to Brain Strain.Journal of biomechanical engineering · 2021Article
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- Development and Application of Digital Human Models in the Field of Vehicle Collisions: A Review.Annals of biomedical engineering · 2021Review
- Group characterization of impact-induced,Journal of the Royal Society, Interface · 2021Article
- Instantaneous Whole-Brain Strain Estimation in Dynamic Head Impact.Journal of neurotrauma · 2021Article
- Natural oscillatory modes of 3D deformation of the human brain in vivo.Journal of biomechanics · 2021Article
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2 authors.
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Abstract
Successful validation of a head injury model is critical to ensure its biofidelity. However, there is an ongoing debate on what experimental data are suitable for model validation. Here, we report that CORrelation and Analysis (CORA) scores based on the commonly adopted relative brain-skull displacements or recent marker-based strains from cadaveric head impacts may not be effective in discriminating model-simulated whole-brain strains across a wide range of blunt conditions. We used three versions of the Worcester Head Injury Model (WHIM; isotropic and anisotropic WHIM V1.0, and anisotropic WHIM V1.5) to simulate 19 experiments, including eight high-rate cadaveric impacts, seven mid-rate cadaveric pure rotations simulating impacts in contact sports, and four in vivo head rotation/extension tests. All WHIMs achieved similar average CORA scores based on cadaveric displacement (~ 0.70; 0.47-0.88) and strain (V1.0: 0.86; 0.73-0.97 vs. V1.5: 0.78; 0.62-0.96), using the recommended settings. However, WHIM V1.5 produced ~ 1.17-2.69 times strain of the two V1.0 variants with substantial differences in strain distribution as well (Pearson correlation of ~ 0.57-0.92) when comparing their whole-brain strains across the range of blunt conditions. Importantly, their strain magnitude differences were similar to that in cadaveric marker-based strain (~ 1.32-3.79 times). This suggests that cadaveric strains are capable of discriminating head injury models for their simulated whole-brain strains (e.g., by using CORA magnitude sub-rating alone or peak strain magnitude ratio), although the aggregated CORA may not. This study may provide fresh insight into head injury model validation and the harmonization of simulation results from diverse head injury models. It may also facilitate future experimental designs to improve model validation.
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