Evidence map›Paper›PMID 32240402›Full record

ReviewCurrent pain and headache reports2020

Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain.

Alan David Kaye, David J Chernobylsky, Pankaj Thakur, Harish Siddaiah, Rachel J Kaye, Lauren K Eng, Monica W Harbell, Jared Lajaunie, Elyse M Cornett

4 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current pain and headache reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 106 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 8 pooled it
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06067893 phase4enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Dexmedetomidine as a Pain Management Adjunct in the Pediatric Population Undergoing Posterior Spinal Fusion

TypeinterventionalSponsorNichole DoyleRan2024 to 2027Enrolled160ConditionsSpinal Fusion, Adolescent Idiopathic ScoliosisArmsDexmedetomidine, Normal Saline
NCT06231979 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block in Lumbar Fusion Surgeries

TypeinterventionalSponsorAssiut UniversityRan2024 to 2025Enrolled48ConditionsErector Spinae Block, Lumbar Fusion Surgeries, DexmedetomidineArmsDexmedetomidine, Bupivacain, Normal saline
NCT07073846 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled104ConditionsMorbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative AnalgesiaArmsIntravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia, 0.9 % Saline Placebo + Standard Anesthesia
NCT07238101 phase4completednot on this mapstarted 2024, after this paper: background citation

Hemodynamic Effects of Fentanyl and Dexmedetomidine in Spine Surgery

TypeinterventionalSponsorUniversitas Sumatera UtaraRan2024 to 2025Enrolled50ConditionsSpine Surgery, Hemodynamic Stability During AnesthesiaArmsDexmedetomidine, fentanyl
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 8 syntheses or guidelines pooled it, 224 citations in OpenAlex.

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  18. Clinical observation of dexmedetomidine nasal spray in the treatment of sleep disorders on the first night after undergoing maxillofacial surgery: a single-center double-blind randomized controlled study.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2023
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Alan David KayeDepartment of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University School of Medicine, Shreveport, LA, USA.
David J ChernobylskyTulane University School of Medicine, New Orleans, LA, 70112, USA.
Pankaj ThakurDepartment of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Harish SiddaiahDepartment of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Rachel J KayeMedical University of South Carolina, Charleston, SC, 29425, USA.
Lauren K EngTulane University School of Medicine, New Orleans, LA, 70112, USA.
Monica W HarbellDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.
Jared LajaunieDepartment of Anesthesiology, LSU Health Sciences Center, Room 656, 1542 Tulane Ave., New Orleans, LA, 70112, USA.
Elyse M CornettDepartment of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA. ecorne@lsuhsc.edu.
Louisiana State University Health Sciences Center Shreveport · USTulane University · USLouisiana State University Health Sciences Center New Orleans · USLouisiana State University in Shreveport · USMayo Clinic in Arizona · USMedical University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewEffective acute pain management has evolved considerably in recent years and is a primary area of focus in attempts to defend against the opioid epidemic. Persistent postsurgical pain (PPP) has an incidence of up to 30-50% and has negative outcome of quality of life and negative burden on individuals, family, and society. The 2016 American Society of Anesthesiologists (ASA) guidelines states that enhanced recovery after surgery (ERAS) forms an integral part of Perioperative Surgical Home (PSH) and is now recommended to use a multimodal opioid-sparing approach for management of postoperative pain. As such, dexmedetomidine is now being used as part of ERAS protocols along with regional nerve blocks and other medications, to create a satisfactory postoperative outcome with reduced opioid consumption in the Post anesthesia care unit (PACU). RECENT

findingsDexmedetomidine, a selective alpha

Indexed as

Enhanced Recovery After SurgeryAnalgesics, Non-NarcoticDexmedetomidineHumansPain ManagementPostoperative PainAnalgesics, Non-NarcoticDexmedetomidineAlpha 2 antagonistsChronic painClonidineDexmedetomidineERAS

Identifiers

PMID32240402
PMCPMC7223065
OpenAlexW3014391478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.