ArticlePloS one2020
Anesthesia with sevoflurane or isoflurane induces severe hypoglycemia in neonatal mice.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Assessment of Temperature Monitoring Techniques in Neonatal and Juvenile BALB/cJ and C57BL/6J Mice (Mus musculus) as They Age.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Acute Comparative Analysis of Anesthetic Methods in Neonatal Mice (Mus musculus) Using Ultrasonic Vocalizations and Biochemical Markers.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Mechanisms of Fat Mass and Obesity-Associated Protein in Regulating Cognitive Impairment Induced by Sevoflurane Anesthesia in Neonatal Rats.Neurochemical research · 2025Article
- Hyperglycemia in Pet African Pygmy Hedgehogs (Animals : an open access journal from MDPI · 2025Article
- Role of ENaC in gender-associated differences in blood pressure.Iranian journal of basic medical sciences · 2025Article
- Article
- Neonatal Anesthesia and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2022Review
- Oral Administration ofFrontiers in immunology · 2022Article
- Effect of remifentanil combined with sevoflurane inhalation anesthesia on coagulation function and postoperative recovery of patients undergoing endoscopic selective varices devascularization.American journal of translational research · 2021Article
- Isoflurane and Carbon Dioxide Elicit Similar Behavioral Responses in Rats.Animals : an open access journal from MDPI · 2020Article
- Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin.American journal of translational research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sevoflurane and isoflurane are among the most commonly used general anesthetics for children including infants, but their impact on metabolism, especially on blood glucose level, in children is not well understood. We investigated the impacts of anesthesia of neonatal (7-8 days old) and adult (2-3 months old) mice with the inhalational anesthetics 2.5% sevoflurane or 1.5% isoflurane, or the injectable anesthetics propofol (150 mg/kg) or avertin (375 mg/kg), for up to 6 hours. We found that sevoflurane and isoflurane induced severe hypoglycemia in neonatal mice and that this phenomenon was specific to the inhalational anesthetics because the injectable anesthetics propofol and avertin did not induce hypoglycemia. Surprisingly, the inhalational anesthesia induced hyperglycemia instead in adult mice. We also demonstrated that the inhalational anesthesia-induced hypoglycemia was a major cause of death for the neonatal mice receiving intranasal administration of saline prior to anesthesia. These studies revealed severe hypoglycemia in neonatal mice during anesthesia with sevoflurane or isoflurane. If this phenomenon also occurs in human, our findings would warrant closely monitoring blood glucose level and maintaining it in the normal range in infants receiving inhalational anesthesia.
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