SynthesisPloS one2020
Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07455981 (Assessment of the Interaction Between Atypical Working Hours and/or Periods of Inactivity on Risky Gambling Practices Among Adults Working Under These Conditions.), which is not on this map. Cited by 94 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of the Interaction Between Atypical Working Hours and/or Periods of Inactivity on Risky Gambling Practices Among Adults Working Under These Conditions.
Who cites it
94 citing papers in PubMed, 7 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- Night shift work and breast cancer risk in healthcare workers: a systematic review and meta-analysis.Occupational medicine (Oxford, England) · 2025Pooled it
- The association between long working hours, shift work, and suicidal ideation: A systematic review and meta-analyses.Scandinavian journal of work, environment & health · 2024Pooled it
- Pregnancy, obstetrical and neonatal outcomes in women exposed to physician-related occupational hazards: a scoping review.BMJ open · 2023Pooled it
- How the reduction of working hours could influence health outcomes: a systematic review of published studies.BMJ open · 2022Pooled it
- Shift work is significantly and positively associated with possible gastro-esophageal reflux disease: A meta-analysis study.Frontiers in public health · 2022Pooled it
- What do we know about the effect of night-shift work on cardiovascular risk factors? An umbrella review.Frontiers in public health · 2022Pooled it
- Psychosocial work exposures and health outcomes: a meta-review of 72 literature reviews with meta-analysis.Scandinavian journal of work, environment & health · 2021Pooled it
- Digital cognitive behavioural therapy for insomnia reduces insomnia in nurses suffering from shift work disorder: A randomised-controlled pilot trial.Journal of sleep research · 2024Trial
- Sleep deprivation affects gait control.Scientific reports · 2021Trial
- Association of shift work and shift patterns with thyroid function: A NHANES-based cross-sectional study.Medicine · 2026Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Associations of weekly working hours with biological aging and all-cause and cardiovascular mortality: the role of lifestyle.Journal of occupational medicine and toxicology (London, England) · 2026Article
- Neonatal nurse practitioners' perspective on fatigue, safety, and collaboration during 24-hour shifts in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Health Behaviours in Soccer Support Staff: 24-Hour Movement Adherence Is Positively Associated with Diet Quality.Sports (Basel, Switzerland) · 2026Article
- Integration of circadian and hypoxia signaling via non-canonical heterodimerization.FEBS letters · 2026Review
- Adaptation of a cardiovascular quality improvement initiative for worksite health centers: application of the ADAPT-ITT framework.Implementation science communications · 2026Article
- Night work and cancer risk: results from the ELSA-Brasil worker cohort.Revista de saude publica · 2026Article
- Prevalence of hypertension and associated factors among nurses working in private and public tertiary hospitals in Dar Es Salaam, Tanzania.PLOS global public health · 2026Article
- Unexplored dimension of shift work: the effects of late-early shifts on nurses and their wellbeing - a qualitative study.BMC nursing · 2025Article
- Prevalence of Overnight Work (1 a.m. to 5 a.m.) Among United States Workers.American journal of industrial medicine · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious reviews have demonstrated that shift work and long work hours are associated with increased risk for chronic conditions. However, these reviews did not comprehensively assessed the body of evidence, and some were not conducted in a systematic manner. A better understanding of the health consequences of shift work and long work hours will aid in creating policy and practice recommendations. This review revisits the epidemiologic evidence on the association of shift work and long work hours with chronic conditions with particular emphasis on assessing the quality of the evidence. METHODS AND
findingsWe conducted a systematic review of systematic reviews with meta-analyses (SR-MA) that assessed the link between shift work or long work hours and chronic conditions (PROSPERO CRD42019122084). We evaluated the risk of bias of each SR-MA using AMSTAR v2 and assessed the overall evidence for each condition using the GRADE approach. We included 48 reviews covering cancers, cardiovascular diseases, metabolic syndrome and related conditions, pregnancy complications, depression, hypertension, and injuries. On average, only 7 of 16 AMSTAR items were fulfilled. Few SR-MAs had a registered protocol and nearly all failed to conduct a comprehensive search. We found moderate grade evidence linking shift work to breast cancer and long work hours to stroke. We found low grade evidence linking both shift work and long work hours with low to moderate increase in risk for some pregnancy complications and cardiovascular diseases. Low grade evidence also link long work hours and depression.
conclusionsModerate grade evidence suggest that shift work and long work hours increase the risk of breast cancer and stroke, but the evidence is unclear on other chronic conditions. There is a need for high-quality studies to address this gap. Stakeholders should be made aware of these increased risks, and additional screening and prevention should be considered, particularly for workers susceptible to breast cancer and stroke.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.