ArticlePloS one2020
Anterior and posterior ratio of corneal surface areas: A novel index for detecting early stage keratoconus.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Early Detection of Keratoconus: Diagnostic Advances and Their Impact on Visual Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Accuracy of new Corvis ST parameters for detecting subclinical and clinical keratoconus eyes in a Chinese population.Scientific reports · 2021Trial
- Comparison of the Ratio Between Anterior and Posterior Curvature Centered on the Thinnest Point (A/B Ratio) in Normal and Keratoconus Eyes.Translational vision science & technology · 2026Article
- Evaluating the Global Consensus on Keratoconus and Ectatic Diseases Agreements Reached on Subclinical Keratoconus.American journal of ophthalmology · 2025Review
- Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies.Eye and vision (London, England) · 2025Review
- Agreement between swept-source OCT and Scheimpflug biometers in ocular measurements.BMC ophthalmology · 2025Article
- Multi-modal imaging for the detection of early keratoconus: a narrative review.Eye and vision (London, England) · 2024Review
- Parameters of a basic ophthalmic examination that can ensure proper timing of corneal crosslinking in patients with keratoconus.International ophthalmology · 2023Review
- Quantitative interocular comparison of total corneal surface area and corneal diameter in patients with highly asymmetric keratoconus.Scientific reports · 2022Article
- Anterior segment characteristics in normal and keratoconus eyes evaluated with a new type of swept-source optical coherence tomography.PloS one · 2022Article
- Quantitative comparison of corneal surface areas in keratoconus and normal eyes.Scientific reports · 2021Article
- Comparison of Barrett and Kane keratoconic formulae in eyes with only posterior corneal changes.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the diagnostic ability of the ratio of anterior and posterior corneal surface areas (As/Ps) comparing with other keratoconus screening indices in distinguishing forme fruste keratoconus (FFKC) from normal eyes.
methodsIn this comparative study, 13 eyes of 13 patients with FFKC, 29 eyes of 29 patients with keratoconus (KC) and 88 eyes of 88 patients with normal subjects were involved. The As/Ps measured by the anterior segment optical coherence tomography (AS-OCT) and other indices measured by AS-OCT and rotating Scheimpflug-based corneal tomography were evaluated. The area under receiver-operating-characteristics (AU-ROC) was calculated to assess the diagnostic ability in discriminating FFKC from normal eyes.
resultsThe As/Ps, the Belin/Ambrosio display enhanced ectasia total derivation value (BAD-D) and posterior and anterior elevation values showed the AU-ROC 0.9 or more in differentiating FFKC from normal eyes (0.980, 0.951, 0.924 and 0.903, respectively). The sensitivity and specificity were 0.92 and 0.96 for the As/Ps, 1.00 and 0.90 for BAD-D, 0.85 and 0.86 for posterior elevation value, and 0.85 and 0.96 for anterior elevation value, respectively.
conclusionsAmong the several indices for keratoconus screening which we evaluated, the As/Ps obtained by AS-OCT had the large AU-ROC with high sensitivity and specificity in detecting FFKC, which was comparable with BAD-D obtained by rotating Scheimpflug-based corneal tomography. The As/Ps may provide information for improving the diagnostic accuracy of KC, even in the initial stage of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.