Evidence map›Paper›PMID 32240016›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020

Combined influence of inspiratory loading and locomotor subsystolic cuff inflation on cardiovascular responses during submaximal exercise.

Joshua R Smith, Eric J Bruhn, Jessica D Berg, Amran A Nur, Nicolas Villarraga, Thomas P Olson

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joshua R SmithDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.ORCID 0000-0002-3687-6261
Eric J BruhnDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.
Jessica D BergDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.
Amran A NurDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.
Nicolas VillarragaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.
Thomas P OlsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.

Funding

Peripheral Mechanisms of Cardiopulmonary Control during ExerciseR01HL126638 · NHLBI · MAYO CLINIC ROCHESTER · PI OLSON, THOMAS PATRICK · 2015 to 2019
$2.9M
NHLBI NIH HHS R01 HL126638
6 · The paper itself

Abstract

It is unknown if simultaneous stimulation of the respiratory and locomotor muscle afferents via inspiratory loading (IL) and locomotor subsystolic cuff inflation (CUFF) influences the cardiovascular responses during exercise. We hypothesized that combined IL and CUFF (IL + CUFF) will result in greater increases in blood pressure (MAP) and systemic vascular resistance (SVR) than IL and CUFF alone during exercise. Eight adults (6 males/2 females) were enrolled and performed four 10-min bouts of constant-load cycling eliciting 40% maximal oxygen uptake on a single day. For each exercise bout, the first 5 min consisted of spontaneous breathing. The second 5 min consisted of voluntary hyperventilation (i.e., breathing frequency of 40 breaths/min) with IL (30% maximum inspiratory pressure), CUFF (80 mmHg), IL + CUFF, or no intervention (CTL) in randomized order. During exercise, cardiac output and MAP were determined via open-circuit acetylene wash-in and manual sphygmomanometry, respectively, and SVR was calculated. Across CTL, IL, CUFF, and IL + CUFF, MAP was greater with each condition (CTL: 97 ± 14; IL: 106 ± 13; CUFF: 114 ± 14; IL + CUFF: 119 ± 15 mmHg, all

Indexed as

Cardiovascular SystemRespiratory MusclesBlood PressureExerciseFemaleHumansMaleMuscle, SkeletalReflexVascular Resistanceblood pressurecardiac outputexercise pressor reflexrespiratory muscle metaboreflexvenous distention

Identifiers

PMID32240016
PMCPMC7272751

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.