ArticleJournal of biomedical materials research. Part B, Applied biomaterials2020
Influence of pre-freezing conditions of octacalcium phosphate and collagen composite for reproducible appositional bone formation.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Histological and radiographic evaluation of bone formation following alveolar ridge preservation using octacalcium phosphate collagen composite: A prospective non-randomized controlled clinical trial.Clinical oral investigations · 2026Article
- Structurally optimized honeycomb scaffolds with outstanding ability for vertical bone augmentation.Journal of advanced research · 2022Article
- Influence of pre-freezing conditions of octacalcium phosphate and collagen composite for reproducible appositional bone formation.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2020Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though conventionally prepared octacalcium phosphate and collagen composite (OCP/Col) has exhibited excellent bone regeneration and has recently been commercialized for treating bone defects, reproducible appositional bone formation with OCP/Col has never been achieved. The present study investigated whether appositional bone formation could be achieved by altering the density of OCP/Col and applying liquid nitrogen during the preparation of OCP/Col. The prepared OCP/Col disks had eight variations and were divided into categories according to four different type of densities (1.0, 1.3, 1.7, and 2.0) of OCP/Col and two different pre-freezing conditions of gas phase (G group: -80°C) and liquid phase (L group: -196°C). These disks were implanted into subperiosteal pockets in rodent calvaria, five samples per each eight variations. Radiomorphometric analysis was conducted at 4 and 12 weeks after implantation, and histological analysis was conducted at 12 weeks after implantation. OCP/Col samples in the L group tended to retain their height and shape and had enhanced appositional bone formation, whereas OCP/Col samples in the G group tended to lose their height and shape and had limited appositional bone formation. The appositional bone formation increased along with growing density of OCP/Col, and L2.0 demonstrated higher appositional bone formation than other samples. These results suggest that the pre-freezing conditions and densities of OCP/Col affect the appositional bone formation.
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