ArticleHuman brain mapping2020
Depth-dependent abnormal cortical myelination in first-episode treatment-naïve schizophrenia.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Cortical Iron and Mesostriatal Dopamine Function in Schizophrenia: A Positron Emission Tomography and Magnetic Resonance Imaging Study.Schizophrenia bulletin · 2026Article
- A frontotemporal free water signature associated to interleukin-8 and cognitive impairment in schizophrenia with comorbidity of metabolic syndrome.Brain, behavior, & immunity - health · 2026Article
- Deficit of oligodendrocyte family cells in layer 5 of the dorsal anterior cingulate cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Cortical myelin mapping in antipsychotic medication-naïve, first-episode psychosis patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Cortical microstructural changes in schizophrenia spectrum disorders using quantitative T1 mapping.Frontiers in psychiatry · 2025Article
- Cognitive impairment in adolescent and adult-onset psychosis: a comparative study.Child and adolescent psychiatry and mental health · 2024Article
- Intracortical myelin across laminae in adult individuals with 47,XXX: a 7 Tesla MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder.Translational psychiatry · 2024Article
- Mass Spectrometry Imaging of Two Neocortical Areas Reveals the Histological Selectivity of Schizophrenia-Associated Lipid Alterations.Consortium psychiatricum · 2024Article
- Neural variability in three major psychiatric disorders.Molecular psychiatry · 2023Article
- Schizophrenia Polygenic Risk During Typical Development Reflects Multiscale Cortical Organization.Biological psychiatry global open science · 2023Article
- Auditory Cortex Thickness Is Associated With N100 Amplitude in Schizophrenia Spectrum Disorders.Schizophrenia bulletin open · 2023Article
- Empirical transmit field bias correction of T1w/T2w myelin maps.NeuroImage · 2022Article
- Reduced number of satellite oligodendrocytes of pyramidal neurons in layer 5 of the prefrontal cortex in schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- T1w/T2w Ratio and Cognition in 9-to-11-Year-Old Children.Brain sciences · 2022Article
- Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?Antioxidants (Basel, Switzerland) · 2021Review
- Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction.Translational psychiatry · 2021Article
- Quantitative Macromolecular Proton Fraction Mapping Reveals Altered Cortical Myelin Profile in Schizophrenia Spectrum Disorders.Cerebral cortex communications · 2021Article
- Depth-dependent abnormal cortical myelination in first-episode treatment-naïve schizophrenia.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myelination is key to effective message passing in the central nervous system and is likely linked to the pathogenesis of schizophrenia (SZ). Emerging evidence indicates that a large portion of intracortical myelin insulates inhibitory interneurons that are highly relevant to pathogenesis of schizophrenia. Here for the first time, we characterized intracortical myelination across the entire cortical surface in first-episode treatment-naïve patients with schizophrenia (FES) using T1w/T2w ratio of structural MRI, FES patients exhibited significantly higher myelin content in the left inferior parietal lobe, supramarginal gyrus, and superior temporal gyrus in the superficial layer, as well as left IPL in the middle layer, but significantly lower myelin content in the left middle insula and posterior cingulate gyrus. Years of education, a proxy for onset of functional decline, significantly altered the relationship between abnormal parietal and posterior cingulate myelination and clinical symptoms, indicating that the pathoplastic role of myelination hinges on the age of onset of functional decline. In addition, higher myelination generally related to better cognitive function in younger subjects but worse cognitive function in older subjects. We conclude that FES is characterized by increased myelination of the superficial layers of the parietal-temporal association cortex, but reduced myelination of the cingulo-insular midcortical layer cortex. Intracortical myelin content affects both cognitive functioning and symptom burden in FES, with the effect conditional upon age and timing of onset of functional decline. These results suggest myelination might be a critical biological target for procognitive interventions in SZ.
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