Evidence map›Paper›PMID 32239722›Full record

SynthesisAnnals of neurology2020

Neurosurgical Intervention for Supratentorial Intracerebral Hemorrhage.

Lotte Sondag, Floris H B M Schreuder, Hieronymus D Boogaarts, Maroeska M Rovers, W Peter Vandertop, Ruben Dammers, Catharina J M Klijn, Dutch ICH Surgery Trial Study Group, part of the CONTRAST consortium†

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06894433 (Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage), which is not on this map. Cited by 66 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 6 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06894433 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage: a Multicenter, Randomized, Controlled Clinical Trial

TypeinterventionalSponsorSouthwest Hospital, ChinaRan2025 to 2028Enrolled280ConditionsIntracerebral HaemorrhageArmsneuroendoscopic surgery, craniotomy
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 6 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Surgery for spontaneous supratentorial intracerebral haemorrhage.The Cochrane database of systematic reviews · 2025
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  17. Controversies in Treatment Methodologies in Cerebrovascular Surgery.Advances and technical standards in neurosurgery · 2026
    Review
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  19. Review
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lotte SondagDepartment of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-2037-7484
Floris H B M SchreuderDepartment of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.
Hieronymus D BoogaartsDepartment of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands.
Maroeska M RoversDepartments of Operating Rooms and Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
W Peter VandertopDepartment of Neurosurgery, Neurosurgical Center Amsterdam, Amsterdam University Medical Centers, VU University Medical Center, Amsterdam, the Netherlands.
Ruben DammersDepartment of Neurosurgery, Erasmus Medical Center, Erasmus MC Stroke Center, Rotterdam, the Netherlands.
Catharina J M KlijnDepartment of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-8495-4578
Dutch ICH Surgery Trial Study Group, part of the CONTRAST consortium†
Radboud University Nijmegen · NLAmsterdam UMC Location University of Amsterdam · NLErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe effect of surgical treatment for supratentorial spontaneous intracerebral hemorrhage (ICH) and whether it is modified by key baseline characteristics and timing remains uncertain.

methodsWe performed a systematic review and meta-analysis of randomized controlled trials of surgical treatment of supratentorial spontaneous ICH aimed at clot removal. We searched MEDLINE, Embase, and Cochrane databases up to February 21, 2019. Primary outcome was good functional outcome at follow-up; secondary outcomes were death and serious adverse events. We analyzed all types of surgery combined and minimally invasive approaches separately. We pooled risk ratios with 95% confidence intervals and assessed the modifying effect of age, Glasgow Coma Scale, hematoma volume, and timing of surgery with meta-regression analysis.

resultsWe included 21 studies with 4,145 patients; 4 (19%) were of the highest quality. Risk ratio of good functional outcome after any type of surgery was 1.40 (95% confidence interval [CI] = 1.22-1.60, I

interpretationSurgical treatment of supratentorial spontaneous ICH may be beneficial, in particular with minimally invasive procedures and when performed soon after symptom onset. Further well-designed randomized trials are needed to demonstrate whether (minimally invasive) surgery improves functional outcome after ICH and to determine the optimal time window of the treatment after symptom onset. ANN NEUROL 2020;88:239-250.

Indexed as

Cerebral HemorrhageHumansMinimally Invasive Surgical ProceduresNeurosurgical ProceduresRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID32239722
PMCPMC7497162
OpenAlexW3015067555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.