SynthesisHuman genetics2020
Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 39% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases.BMC medical genomics · 2022Pooled it
- Article
- Exploring molecular links between obesity and osteoporosis: insights from in-silico analysis and mannose supplementation.Scientific reports · 2025Article
- Post-infectious cough in patients with obesity: an observational study.Frontiers in medicine · 2025Article
- Genome-wide association study of osteoporosis identifies genetic risk and interactions with Dietary Approaches to Stop Hypertension diet and sugar-sweetened beverages in a Hispanic cohort of older adults.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population.Metabolites · 2021Article
- MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin.International journal of molecular sciences · 2021Article
- Association of Fibroblast Growth Factor 23 With Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.Frontiers in genetics · 2020Article
- A network pharmacology approach to explore and validate the potential targets of ginsenoside on osteoporosis.International journal of immunopathology and pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Lu LiuCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.
Xiao-Lin YangCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.
Hong ZhangCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.
Zi-Jia ZhangPeople's Hospital of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China.
Xin-Tong WeiJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Gui-Juan FengJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Ju LiuKunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, People's Republic of China.
Hui-Ping PengKunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, People's Republic of China.
Rong HaiHealth Commission of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China.
Hui ShenTulane Center for Genomics and Bioinformatics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA.
Qing TianTulane Center for Genomics and Bioinformatics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA.
Hong-Wen DengTulane Center for Genomics and Bioinformatics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA. hdeng2@tulane.edu.
Yu-Fang PeiJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China. ypei@suda.edu.cn.
Lei ZhangCenter for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China. lzhang6@suda.edu.cn.
Soochow University · CNTulane University · USShanghai University of Traditional Chinese Medicine · CNInner Mongolia People's Hospital · CNTraditional Chinese Medicine Hospital of Kunshan · CN
Funding
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3MTrans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI HONG-WEN DENG · 2017 to 2026
$24.3MRISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1MMultivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8MNutrigenetics and Nutrigenomics for Precision Weight-Loss Diet InterventionsR01DK115679 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Lu Qi · 2018 to 2026
$5.3MMale/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8MEpigenomewide DNA Methylation Study for Osteoporosis RiskR01AR059781 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, HONG-WEN · 2012 to 2016
$3.1MIdentification of Metabolomic Profiles for Sarcopenia Traits in Older Whites and BlacksR01AG061917 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SHEN, HUI, ZHAO, QI · 2019 to 2023
$3.0MDecoding Methylation Mediated Epigenomic Contributions to Male OsteoporosisR01AR069055 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, HONG-WEN · 2017 to 2021
$2.9MUnified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7MIntegration of brain imaging with genomic and epigenomic dataR01MH104680 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI CALHOUN, VINCE D, DENG, HONG-WEN · 2014 to 2017
$2.1MIntegration of fMRI imaging, genomics, network and biological knowledgeR01MH107354 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2015 to 2018
$1.9MInner Mongolia Autonomous Region medical health science & technology research program 201702180National Natural Science Foundation of China 31501026National Natural Science Foundation of China 31571291National Natural Science Foundation of China 31771417NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N02 HL064278NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR059781NIAMS NIH HHS R01 AR069055NIA NIH HHS R01 AG061917NIA NIH HHS U19 AG055373NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIDDK NIH HHS R01 DK115679NIGMS NIH HHS P20 GM109036NIGMS NIH HHS R01 GM109068NIH HHS R01DK115679NIH HHS R01GM109068NIH HHS R01MH107354NIMH NIH HHS R01 MH104680NIMH NIH HHS R01 MH107354NIMH NIH HHS R01 MH118695WHI NIH HHS N01 WH022110
Abstract
Aiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we performed a bivariate GWAS meta-analysis of femoral neck BMD (FNK-BMD) and trunk fat mass adjusted by trunk lean mass (TFM
Indexed as
AnimalsBody Mass IndexCohort StudiesFemaleFemur NeckGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInterferon-gammaMaleMendelian Randomization AnalysisMiceMice, KnockoutObesity, AbdominalIFNG protein, humanInterferon-gammaPRKCQ protein, humanProtein Kinase C-theta
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.