Evidence map›Paper›PMID 32239315›Full record

ReviewDocumenta ophthalmologica. Advances in ophthalmology2020

Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review.

Kei Mizobuchi, Takaaki Hayashi, Satoshi Katagiri, Euido Kim, Yasutsugu Ishiba, Sumiko Watanabe, Takahisa Furukawa, Tadashi Nakano

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Documenta ophthalmologica. Advances in ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kei MizobuchiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan. taka@jikei.ac.jp.
Satoshi KatagiriDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Euido KimDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Yasutsugu IshibaDivision of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Sumiko WatanabeDivision of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Takahisa FurukawaLaboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka, Japan.
Tadashi NakanoDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Jikei University School of Medicine · JPThe University of Tokyo · JPProtein Research Foundation · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report a patient with thymoma-associated retinopathy presenting as having a good visual prognosis.

methodsCase report and literature review. CASE REPORT: A 42-year-old female patient was referred to our hospital for complaints of sudden visual-field defects bilaterally. Decimal corrected visual acuity (VA) was 1.5 and 1.2 in the right (RE) and left eyes (LE), respectively. Fundus autofluorescence revealed hyper-autofluorescence from the posterior pole to mid-peripheral retina in both eyes. Full-field electroretinography (ERG) amplitudes were reduced to 20-50% and 30-50% of our controls for the scotopic and photopic conditions, respectively. A systemic examination revealed the presence of thymoma, and the patient underwent thymectomy and immunosuppression therapies. Immunohistochemical analysis using the patient's serum showed immunolabeling on the photoreceptor inner segment and outer plexiform layer in the monkey retina. Two years later, VA remained at 1.5 and 1.2 in RE and LE. ERG amplitudes improved to 30-60% of the controls for the scotopic conditions. However, photopic ERG showed no remarkable change.

conclusionsTo our knowledge, improvement of reduced rod-mediated ERG responses has not been described in seven previously reported patients with thymoma-associated retinopathy. The good visual prognosis of our patient may be associated with well-timed intervention.

Indexed as

AdultCombined Modality TherapyElectroretinographyFemaleHumansImmunosuppressive AgentsParaneoplastic Syndromes, OcularRetinal Rod Photoreceptor CellsThymectomyThymomaThymus NeoplasmsTomography, Optical CoherenceVision DisordersVisual AcuityVisual FieldsImmunosuppressive AgentsElectroretinographyImmunohistochemistryImmunosuppression therapyParaneoplastic retinopathyThymoma

Identifiers

PMID32239315
OpenAlexW3014871567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.