ReviewJournal of neurology2021
Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.
Review in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Attitudes toward sodium valproate use, withdrawal, and counseling in people of reproductive potential: A scoping review.Epilepsia open · 2026Review
- Therapeutic Strategies After Discontinuation of Valproate By Females with Epilepsy of Child-Bearing Potential: An Insurance Claims Database Study in France and the United Kingdom.Clinical drug investigation · 2026Article
- Epilepsy in children and young people as a stigma throughout history: identifying cultural, religious and educational factors to design strategies for contemporary social inclusion.Frontiers in neurology · 2026Review
- Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system.Epilepsia open · 2025Article
- Whole-cycle management of women with epilepsy of child-bearing age: ontology construction and application.BMC medical informatics and decision making · 2024Article
- The valproate prescription pattern for female mental healthcare users of reproductive age.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Monitoring of the trough concentration of valproic acid in pediatric epilepsy patients: a machine learning-based ensemble model.Frontiers in pharmacology · 2024Article
- Replacement of Valproic Acid with New Anti-Seizure Medications in Idiopathic Generalized Epilepsy.Journal of clinical medicine · 2022Article
- Treatment outcomes in women with idiopathic generalized epilepsy.Acta neurologica Scandinavica · 2022Article
- Sodium Valproate Combined With Topiramate vs. Sodium Valproate Alone for Refractory Epilepsy: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Article
- Longitudinal Australian trends in the initiation of valproate medication among women of reproductive age and concurrent use of prescription contraceptives.Women's health (London, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Valproate is a broad-spectrum antiepileptic drug (AED) of particular interest in pediatric epilepsy syndromes and idiopathic generalized epilepsy, as it is relatively more effective in these syndromes than other AEDs. In 2018, the European Medicines Agency introduced new restrictions on the use of valproate in girls and women of childbearing potential to avoid exposure during pregnancy. The strengthening of existing restrictions sparked controversy and debate among patients and the medical community. The high prevalence of epilepsy syndromes amenable to valproate treatment in women of childbearing age and the little information available on the teratogenic potential of alternative treatments have created uncertainty on how to manage these patients. In this consensus statement, based on a review of the literature and the clinical experience of a panel of European epilepsy experts, we present general recommendations for the optimal clinical management of AED treatment in girls, women of childbearing potential, and pregnant women across the different epilepsy syndromes.
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