ReviewEuropean journal of clinical pharmacology2020
Individual factors increasing complexity of drug treatment-a narrative review.
Review in European journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Prevalence and patient-rated relevance of complexity factors in medication regimens of community-dwelling patients with polypharmacy.European journal of clinical pharmacology · 2022Trial
- Factors associated with medication self-management performance in the "Ability to Self-administer Medication in Non-demented In-hospital Patients" (ABLYMED) study.BMC geriatrics · 2026Observational
- The Spectrum of Clinical Pharmacy Services in a Non-University Hospital-A Comprehensive Characterization Including a Risk Assessment for Drug-Related Problems and Adverse Drug Reactions.Pharmacy (Basel, Switzerland) · 2025Article
- [Frailty and pharmacotherapy].Innere Medizin (Heidelberg, Germany) · 2025Review
- Review
- Effective Therapeutic Strategies to Prevent Frailty and Falls in Community-Dwelling Older Adults.Aging and disease · 2025Review
- Shared decision making - a review of its evaluation, efficacy, and applicability in asthma.Frontiers in medicine · 2025Review
- Impact of pharmacotherapy complexity on self-care in individuals with rheumatoid arthritis.Revista brasileira de enfermagem · 2025Article
- A Novel Screening Method to Prioritise Cardiovascular Patients Receiving a Pharmaceutical Care Intervention and the Effects on Patients' Difficulties with Managing Their Drug Treatment.Patient preference and adherence · 2025Article
- Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders.International journal of molecular sciences · 2024Review
- Polypharmacy and medication regimen complexity in transfusion-dependent thalassaemia patients: a cross- sectional study.International journal of clinical pharmacy · 2024Observational
- Pharmacy practice in hospital settings in GCC countries: Pharmacists' medication therapy monitoring activities.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Tripled likelihood: polypharmacy increases the occurrence of drug therapy problems in hospitalized pediatric patients.Frontiers in pharmacology · 2024Article
- Pharmacist-Managed Therapeutic Drug Monitoring Programs within Australian Hospital and Health Services-A National Survey of Current Practice.Pharmacy (Basel, Switzerland) · 2022Article
- HIOPP-6 - a pilot study on the evaluation of an electronic tool to assess and reduce the complexity of drug treatment considering patients' views.BMC primary care · 2022Article
- Development of an Electronic Tool to Assess Patient Preferences in Geriatric Polypharmacy (PolyPref).Patient preference and adherence · 2022Article
- Development and Pilot-Testing of Key Questions to Identify Patients' Difficulties in Medication Administration.Patient preference and adherence · 2021Article
- Development of an algorithm to detect and reduce complexity of drug treatment and its technical realisation.BMC medical informatics and decision making · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
purposeComplexity of drug treatment is known to be a risk factor for administration errors and nonadherence promoting higher healthcare costs, hospital admissions and increased mortality. Number of drugs and dose frequency are parameters often used to assess complexity related to the medication regimen. However, factors resulting from complex processes of care or arising from patient characteristics are only sporadically analyzed. Hence, the objective of this review is to give a comprehensive overview of relevant, patient-centered factors influencing complexity of drug treatment.
methodsA purposeful literature search was performed in MEDLINE to identify potential complexity factors relating to the prescribed drug (i.e. dosage forms or other product characteristics), the specific medication regimen (i.e. dosage schemes or additional instructions), specific patient characteristics and process characteristics. Factors were included if they were associated to administration errors, nonadherence and related adverse drug events detected in community dwelling adult patients.
resultsNinety-one influencing factors were identified: fourteen in "dosage forms", five in "product characteristics", twelve in "dosage schemes", nine in "additional instructions", thirty-one in "patient characteristics" and twenty in "process characteristics".
conclusionsAlthough the findings are limited by the non-systematic search process and the heterogeneous results, the search shows the influence of many factors on the complexity of drug treatment. However, to evaluate their relevance for individual patients, prospective studies are necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.