Evidence map›Paper›PMID 32239239›Full record

ArticleArchives of toxicology2020

Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice.

Brandon Pressly, Natalia Vasylieva, Bogdan Barnych, Vikrant Singh, Latika Singh, Donald A Bruun, Sung Hee Hwang, Yi-Je Chen, James C Fettinger, Stephanie Johnnides and 4 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABAAnnals of clinical and translational neurology · 2022
    Article
  9. Revision of the Unstable Picrotoxinin Hydrolysis Product.Angewandte Chemie (International ed. in English) · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Brandon Pressly *Department of Pharmacology, Genome and Biomedical Sciences Facility, University of California, Room 3502, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Natalia Vasylieva *Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, USA.
Bogdan BarnychDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, USA.
Vikrant SinghDepartment of Pharmacology, Genome and Biomedical Sciences Facility, University of California, Room 3502, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Latika SinghDepartment of Pharmacology, Genome and Biomedical Sciences Facility, University of California, Room 3502, 451 Health Sciences Drive, Davis, CA, 95616, USA.
Donald A BruunDepartment of Molecular Biosciences, University of California, Davis, USA.
Sung Hee HwangDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, USA.
Yi-Je ChenDepartment of Pharmacology, Genome and Biomedical Sciences Facility, University of California, Room 3502, 451 Health Sciences Drive, Davis, CA, 95616, USA.
James C FettingerDepartment of Chemistry, University of California, Davis, USA.
Stephanie JohnnidesCity University Veterinary Medical Centre, Sham Shui Po, Hong Kong.
Pamela J LeinDepartment of Molecular Biosciences, University of California, Davis, USA.
Jun YangDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, USA.
Bruce D HammockDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, USA.
Heike Wulff *Department of Pharmacology, Genome and Biomedical Sciences Facility, University of California, Room 3502, 451 Health Sciences Drive, Davis, CA, 95616, USA. hwulff@ucdavis.edu.
University of California, Davis · US

Funding

Training and Education CoreU54NS079202 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEIN, PAMELA J · 2012 to 2021
$35.7M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
NIEHS NIH HHS R35 ES030443NIGMS NIH HHS T32 GM099608NINDS NIH HHS U54 NS079202
6 · The paper itself

Abstract

Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-aminobutyric acid type-A (GABA

Indexed as

AnimalsBiotransformationBrainBridged-Ring CompoundsConvulsantsGABA AntagonistsLethal Dose 50MaleMicePicrotoxinReceptors, GABA-ASeizuresSesterterpenesTissue DistributionToxicokineticsBridged-Ring CompoundsConvulsantsGABA AntagonistsGabra2 protein, mouseGabrb3 protein, mouseGabrg2 protein, mousePicrotoxinpicrotoxininReceptors, GABA-ASesterterpenestetramethylenedisulfotetramineConvulsantGABAA receptorPicrotoxininTETSThreat agent

Identifiers

PMID32239239
PMCPMC7303059
OpenAlexW3014508960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.