Evidence map›Paper›PMID 32239237›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Long-term cost-effectiveness of screening for fracture risk in a UK primary care setting: the SCOOP study.

E Söreskog, F Borgström, L Shepstone, S Clarke, C Cooper, I Harvey, N C Harvey, A Howe, H Johansson, T Marshall and 8 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recommendations on screening for primary prevention of fragility fractures.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Guideline
  2. Article
  3. Article
  4. Revised Swedish FRAX models and the establishment of age-dependent intervention thresholds.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Real-world evidence: new opportunities for osteoporosis research. Recommendations from a Working Group from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Review
  12. Article
  13. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Article
  14. Article
  15. Osteoporosis in 2022: Care gaps to screening and personalised medicine.Best practice & research. Clinical rheumatology · 2022
    Review
  16. Article
  17. Neuroendocrine neoplasia and bone (Review).Experimental and therapeutic medicine · 2021
    Review
  18. Article
  19. A brief history of FRAX.Archives of osteoporosis · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

E SöreskogQuantify Research, Stockholm, Sweden.
F BorgströmQuantify Research, Stockholm, Sweden.
L ShepstoneNorwich Medical School, University of East Anglia, Norwich, UK.
S ClarkeDepartment of Rheumatology, University Hospitals Bristol, Bristol, UK.
C CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
I HarveyNorwich Medical School, University of East Anglia, Norwich, UK.
N C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
A HoweNorwich Medical School, University of East Anglia, Norwich, UK.
H JohanssonCentre for Metabolic Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
T MarshallNorfolk and Norwich University Hospital, Norwich, UK.
T W O'NeillNIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
T J PetersBristol Medical School, University of Bristol, Bristol, UK.
N M RedmondBristol Medical School, University of Bristol, Bristol, UK.
D TurnerNorwich Medical School, University of East Anglia, Norwich, UK.
R HollandLeicester Medical School, Centre for Medicine, University of Leicester, Leicester, UK.
E McCloskeyCentre for Metabolic Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
J A KanisCentre for Metabolic Diseases, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. w.j.pontefract@shef.ac.uk.
SCOOP study team

Funding

Medical Research Council G0601019Medical Research Council MC_UU_12011/1Medical Research Council MR/P020941/1Versus Arthritis 17702Versus Arthritis 21231
6 · The paper itself

Abstract

Community-based screening and treatment of women aged 70-85 years at high fracture risk reduced fractures; moreover, the screening programme was cost-saving. The results support a case for a screening programme of fracture risk in older women in the UK.

introductionThe SCOOP (screening for prevention of fractures in older women) randomized controlled trial investigated whether community-based screening could reduce fractures in women aged 70-85 years. The objective of this study was to estimate the long-term cost-effectiveness of screening for fracture risk in a UK primary care setting compared with usual management, based on the SCOOP study.

methodsA health economic Markov model was used to predict the life-time consequences in terms of costs and quality of life of the screening programme compared with the control arm. The model was populated with costs related to drugs, administration and screening intervention derived from the SCOOP study. Fracture risk reduction in the screening arm compared with the usual management arm was derived from SCOOP. Modelled fracture risk corresponded to the risk observed in SCOOP.

resultsScreening of 1000 patients saved 9 hip fractures and 20 non-hip fractures over the remaining lifetime (mean 14 years) compared with usual management. In total, the screening arm saved costs (£286) and gained 0.015 QALYs/patient in comparison with usual management arm.

conclusionsThis analysis suggests that a screening programme of fracture risk in older women in the UK would gain quality of life and life years, and reduce fracture costs to more than offset the cost of running the programme.

Indexed as

Mass ScreeningOsteoporotic FracturesQuality of LifeAgedAged, 80 and overCost-Benefit AnalysisFemaleHumansPrimary Health CareQuality-Adjusted Life YearsUnited KingdomCost-effectivenessFracture risk assessmentFRAXRandomized controlled trialUK

Identifiers

PMID32239237
PMCPMC7115896

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.